Expressions of Bcl-2 and Caspase-3 in the internal organs of rats when tetramine was administered / 法医学杂志
Journal of Forensic Medicine
;
(6): 241-244, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-983188
ABSTRACT
OBJECTIVE@#To find whether Bcl-2 and Caspase-3 take part in the pathophysiological mechanism of tetramine toxification.@*METHODS@#Sixty Sprague-Dawley rats were divided into normal control group, the sham poisoned group, high dose poisoned group, low dose poisoned group. High dose poisoned group were administered 1.0 mg/kg weight body tetramine by mouth, however low dose poisoned group was administered tetramine 0.1 mg/kg weight body by mouth. The rats of the sham poisoned group were administered water, and rats of normal control group were given nothing. Bcl-2 and Caspase-3 were detected by immunohistochemistry staining and the results were assessed by image analysis system.@*RESULTS@#The expressions of Bcl-2 and Caspase-3 in all organs were similar, ie, Bcl-2 and Caspase-3 expressed obviously in all organs of high dose poisoned group; in all organs of low dose poisoned group, they were hardly detected at 30 min after administration, however, at 3 h after administration, they could be detected obviously; Bcl-2 got to peak at 6 h-3 d after administration and Caspase-3 got to peak at 24 h-3 d after administration.@*CONCLUSION@#Bcl-2 and Caspase-3 take part in the pathophysiological procedure of tetramine poisoned rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spleen
/
Time Factors
/
Bridged-Ring Compounds
/
Immunohistochemistry
/
Random Allocation
/
Rats, Sprague-Dawley
/
Proto-Oncogene Proteins c-bcl-2
/
Dose-Response Relationship, Drug
/
Caspase 3
/
Kidney
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2006
Type:
Article
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