Expression of calpain 1 and calpain 2 during the skin incised wound healing in mice / 法医学杂志

ABSTRACT

OBJECTIVE@#To investigate the expressions of calpain1 and calpain2 during the skin incised wound healing in mice.@*METHODS@#Expression of calpain1 and calpain2 was evaluated by immunohistochemical method.@*RESULTS@#Both calpain1 and calpain2 were expressed in the skin cells in the control groups. The calpain1 positive cells were remarkably increased and reached the maximal level in day 1 after skin incised wound, decreased after day 3, markedly increased again in day 5, and then gradually decreased from day 7 to 14; the calpain2 positive cells were significantly increased in day 1 and decreased to the minimum in day 3, markedly increased again in day 5, and then gradually decreased from day 7 to 10.@*CONCLUSION@#The changes of calpain1 and calpain2 expressions appear to be bimodal after incised wound of skin in mice.