Advances in research of ketamine addiction mechanism / 法医学杂志
Journal of Forensic Medicine
;
(6): 200-207, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-983474
ABSTRACT
Ketamine is a phencyclidine derivative acting primarily as a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) excitatory glutamate receptors. As a common intravenous anaesthetic in clinic, it is also increasingly abused because of its hallucination and addiction effects. Based on the pharmacological and toxicologic characteristics of ketamine and the acknowledged addiction mechanism of other abused drugs, this article reviews the possible addiction mechanism of the ketamine in the aspects of its enhanced effects and reward systems, the anatomic structures, the related receptors and the individual differences.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Illicit Drugs
/
Receptors, Dopamine
/
Receptors, N-Methyl-D-Aspartate
/
Substance-Related Disorders
/
Ketamine
/
Anesthetics, Dissociative
/
Mental Disorders
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2009
Type:
Article
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