Immunohistochemical expression of HO-1 in traumatic human brain tissue / 法医学杂志
Journal of Forensic Medicine
; (6): 325-331, 2010.
Article
in Zh
| WPRIM
| ID: wpr-983587
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression of heme oxygenase-1 (HO-1) at different intervals and to provide evidence for estimation on injury intervals after brain contusion in human.@*METHODS@#Twenty-four patients died of serious brain injury were assigned as injury group and 4 patients died of non-brain injury were served as control group. HO-1 expression was analyzed in brain tissue at different time intervals (3 h, 6-9 h, 12-24 h, 36 h-3d, 5-8d, 17-20d) by immunohistochemistry and auto-image analysis system.@*RESULTS@#The level of HO-1 expression started to increase in 3 h after brain contusion compared to the control group (P < 0.05). The level of HO-1 expression highest level in 12-24 h group, and maintained high level in 36 h-3 d, then decreased gradually.@*CONCLUSION@#The expression of HO-1 might be a strong evidence for human brain contusion time estimation.
Full text:
1
Index:
WPRIM
Main subject:
Autopsy
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Staining and Labeling
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Time Factors
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Brain
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Brain Injuries
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Immunohistochemistry
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Case-Control Studies
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Forensic Pathology
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Heme Oxygenase-1
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Forensic Medicine
Year:
2010
Type:
Article