Progress on association between COMT gene and violence behavior in patients with schizophrenia / 法医学杂志
Journal of Forensic Medicine
; (6): 197-201, 2014.
Article
in Zh
| WPRIM
| ID: wpr-983907
Responsible library:
WPRO
ABSTRACT
The prevalence of violence behavior in patients with schizophrenia is higher than that in common population. Data suggest that genetic factors may play a substantial role for the etiology of the behavior. Among the particular gene polymorphisms that have been considered to be involved in violence behavior, the catechol-O-methyltransferase (COMT) gene had been the focus of recent research. This article reviews the association research between COMT gene and violence behavior in patients with schizophrenia in several aspects SNP polymorphism of COMT Val158Met and COMT Ala72Ser, haplotype of COMT gene and DNA methylation of promoter region of COMT gene. The genetic research direction is presented for patients with schizophrenia.
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
/
Schizophrenia
/
Violence
/
Haplotypes
/
Catechol O-Methyltransferase
/
Aggression
Limits:
Humans
Language:
Zh
Journal:
Journal of Forensic Medicine
Year:
2014
Type:
Article