Progress on Hypoxic-ischemic Brain Damage Associated with CCR2 and CCL2 / 法医学杂志
Journal of Forensic Medicine
; (6): 54-57, 2016.
Article
in Zh
| WPRIM
| ID: wpr-984043
Responsible library:
WPRO
ABSTRACT
Hypoxic-ischemic brain damage (HIBD) is referred to a common type of cerebral damage, which is caused by injury, leading to shallow bleeding in the cortex with intact cerebral pia mater. In recent years, studies show that a various kinds of immune cells and immune cellular factors are involved in the occurrence of HIBD. CC chemokine receptor 2 (CCR2) is a representative of CC chemokine receptor, and is widely distributed in cerebral neuron, astrocyte, and microglial cells, and is the main chemo-tactic factor receptor in brain tissue. CC chemokine ligand 2 (CCL2) is a kind of basophilic protein and the ligand of CCR2, and plays an important role in inflammation. In order to provide evidence for correlational studies in HIBD, this review will introduce the biological characteristics of CCR2 and CCL2, and illustrate the relationship between the immunoreactivity and HIBD.
Full text:
1
Index:
WPRIM
Main subject:
Brain Injuries
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RNA, Messenger
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Cerebral Cortex
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Rats, Sprague-Dawley
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Chemokine CCL2
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Macrophage Inflammatory Proteins
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Chemokines, CC
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Hypoxia-Ischemia, Brain
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Receptors, CCR2
Limits:
Animals
Language:
Zh
Journal:
Journal of Forensic Medicine
Year:
2016
Type:
Article