Two Cases of Refractory Thrombocytopenia in Systemic Lupus Erythematosus that Responded to Intravenous Low-Dose Cyclophosphamide
Journal of Korean Medical Science
; : 472-475, 2013.
Article
in En
| WPRIM
| ID: wpr-98476
Responsible library:
WPRO
ABSTRACT
Treatment of thrombocytopenia in systemic lupus erythematosus (SLE) is considered in cases of current bleeding, severe bruising, or a platelet count below 50,000/microliter. Corticosteroid is the first choice of medication for inducing remission, and immunosuppressive agents can be added when thrombocytopenia is refractory to corticosteroid or recurs despite it. We presented two SLE patients with thrombocytopenia who successfully induced remission after intravenous administration of low-dose cyclophosphamide (CYC) (500 mg fixed dose, biweekly for 3 months), followed by azathioprine (AZA) or mycophenolate mofetil (MMF). Both patients developed severe thrombocytopenia in SLE that did not respond to pulsed methylprednisolone therapy, and started the intravenous low-dose CYC therapy. In case 1, the platelet count increased to 50,000/microliter after the first CYC infusion, and remission was maintained with low dose prednisolone and AZA. The case 2 achieved remission after three cycles of CYC, and the remission continued with low dose prednisolone and MMF.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Platelet Count
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Azathioprine
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Thrombocytopenia
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Bone Marrow
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Infusions, Intravenous
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Cyclophosphamide
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Drug Therapy, Combination
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Immunosuppressive Agents
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Lupus Erythematosus, Systemic
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Mycophenolic Acid
Limits:
Female
/
Humans
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article