Persistence follow-up of immune memory to hepatitis B vaccine among infants with non- and low-response to primary vaccination after revaccination with three doses / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 732-735, 2023.
Article
in Zh
| WPRIM
| ID: wpr-985465
Responsible library:
WPRO
ABSTRACT
This study followed up the immune memory after 3-dose revaccination among infants with non-and low-response following primary hepatitis B (HepB) vaccination. About 120 children without self-booster doses were finally included who had anti-HBs<10 mIU/ml (anti-HBs negative) at the time of follow-up, of whom 86 children completed blood sampling and anti-HBs testing. Before the challenge dose, all 86 children were negative for anti-HBs, and the GMC of anti-HBs was<10 mIU/ml. The seropositive conversion rate of anti-HBs was 100% and the GMC of anti-HBs was 886.11 (95%CI 678.15-1 157.84) mIU/ml after the challenge dose. Compared with those with GMC<7 mIU/ml before the challenge dose, infants with GMC>7 mIU/ml had a higher anti-HBs level after the challenge dose. The β value (95%CI) was 0.82 (0.18-1.46) (P=0.012). Compared with those with GMC<1 000 mIU/ml at primary vaccination, infants with GMC≥1 000 mIU/ml had a higher anti-HBs level after the challenge dose. The β value (95%CI) was 0.78 (0.18-1.38)(P=0.012). The results showed a stronger immune memory was found at 9 years after revaccination among infants with non-and low-response to HepB.
Full text:
1
Index:
WPRIM
Main subject:
Follow-Up Studies
/
Immunization, Secondary
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Vaccination
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Hepatitis B Vaccines
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Hepatitis B
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Hepatitis B Antibodies
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Hepatitis B Surface Antigens
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Immunologic Memory
Limits:
Child
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Humans
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Infant
Language:
Zh
Journal:
Chinese Journal of Preventive Medicine
Year:
2023
Type:
Article