Effects of specimen preservation and transportation on blood paraquat concentration in rats / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 447-450, 2023.
Article
in Zh
| WPRIM
| ID: wpr-986048
Responsible library:
WPRO
ABSTRACT
Objective:
To investigate the effects of duration, temperature and shake on paraquat (PQ) concentration in the blood of PQ-exposed rats during the specinen preservation and transportation.Methods:
In March 2021, 60 SD male rats of Specific Pathogen Free class were randomly divided into low-dose group (10 mg/kg PQ) and high-dose group (80 mg/kg PQ). Each group was divided into 5 subgroups (normal temperature group, cold storage group, 37 ℃ storage group, shaking on normal temperature group and shaking on 37 ℃ group), six rats in each subgroup. The rats were given intraperitoneal injection of PQ, 1 h after exposure, the blood samples were obtained by cardiac extraction. After different interventions, the concentrations of PQ were detected and compared before and after the intervention in each subgroup.Results:
In the shaking on 37 ℃ group, the results of PQ concentrations in PQ-exposed rats were significantly lower than those before the intervention (P<0.05). In the other subgroups, the results were not significantly different compared with before intervention (P>0.05) .Conclusion:
The concentration of PQ in the blood of rats exposed to PQ was decreased by shaking for 4 hours at 37 ℃.Key words
Full text:
1
Index:
WPRIM
Main subject:
Paraquat
/
Rats, Sprague-Dawley
/
Lung
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2023
Type:
Article