Correlations of systolic blood pressure with uric acid, blood lipid and blood glucose / 预防医学

ABSTRACT

Objective@#To analyze the correlations of systolic blood pressure (SBP) with uric acid, blood lipid and blood glucose in adults, so as to provide the evidence for blood pressure management and early prevention of cardiovascular diseases. @*Methods@# Based on the China Health and Nutrition Survey, data of participants in 2004 and 2009 was collected, including demographic characteristics, blood pressure, uric acid, blood lipid and blood glucose. Participants with SBP<140 mmHg both in 2004 and 2009 were divided into the continuously normal group, participants with SBP≥140 mmHg in 2004 and <140 mmHg in 2009 were divided into the reduced group, participants with SBP<140 mmHg in 2004 and ≥140 mmHg in 2009 were divided into the elevated group, and participants with SBP≥140 mmHg both in 2004 and 2009 were divided into the continuously high group. Multivariable logistic regression model was used to analyze the correlations of SBP with uric acid, blood lipid and blood glucose. @*Results@#A total of 5 086 subjects were included in this study with a mean age of (48.0±7.2) years, including 2 374 males (46.67%) and 2 712 women (53.33%). The median (interquartile range) of SBP was 117.00 (13.33) mmHg in the continuously normal group, 146.67 (15.33) mmHg in the reduced group, 122.67 (12.00) mmHg in the elevated group and 150.67 (18.66) mmHg in the continuously high group. Multivariable logistic regression analysis showed that compared with the continuously normal group, the reduced group was correlated with abnormal fasting blood glucose (OR=1.383, 95%CI 1.008-1.896); the elevated group was correlated with abnormal uric acid (OR=1.495, 95%CI 1.195-1.869), abnormal low density lipoprotein cholesterol (OR=1.226, 95%CI 1.030-1.460), abnormal triglyceride (OR=1.446, 95%CI 1.203-1.739) and abnormal total cholesterol (OR=1.261, 95%CI 1.057-1.504); the continuously high group was correlated with abnormal uric acid (OR=1.603, 95%CI 1.188-2.164), abnormal triglyceride (OR=1.619, 95%CI 1.253-2.093) and abnormal fasting blood glucose (OR=1.565, 95%CI 1.166-2.100), adjusting for confounding factors (gender, age, marital status, etc.).@*Conclusion@# The increase of SBP in adults were correlated with uric acid, blood lipid and blood glucose.