Lack of the Association between Microsatellite Polymorphism in Toll-like Receptor 2 Gene and Development of COPD / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 367-374, 2005.
Article
in Korean
| WPRIM
| ID: wpr-99076
ABSTRACT
BACKGROUND:
The fact that only 10-20% of chronic cigarette smokers develop chronic obstructive pulmonary disease (COPD) reflects the presence of genetic factors associated with the susceptibility to COPD. Recently, it was reported that the surfactant protein A increases the secretion of matrix metalloprotease 9, which degrades extracellular matrices of the lung, through a Toll-like receptor 2 (TLR2). In this context, possible role of TLR2 in the pathogenesis of COPD was postulated, and a functional dinucleotide repeat polymorphism in intron II of TLR2 was evaluated for any association with COPD.METHOD:
Male patients with COPD and male smokers with a normal pulmonary function were enrolled in this study. The number of Guanine-Thymine repeats in intron II of the TLR2 gene were counted. Because the distributions of the repeats were trimodal, the alleles were classified into three subclasses, 12-16 repeats short (S) alleles; 17-22 repeats medium length (M) alleles; and 23-27 repeats long (L) alleles.RESULT:
125 male patients with COPD and 144 age- and gender-matched blood donors with a normal lung function were enrolled. There were no differences in the distribution of each allele subclass (S, M and L) between the COPD and control group (p=0.75). The frequencies of the genotypes with and without each allele subclass in the COPD and control group were similar.CONCLUSION:
A microsatellite polymorphism in intron II of TLR2 gene was not associated with the development of COPD in Koreans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Donors
/
Introns
/
Microsatellite Repeats
/
Dinucleotide Repeats
/
Genetic Predisposition to Disease
/
Pulmonary Disease, Chronic Obstructive
/
Pulmonary Surfactant-Associated Protein A
/
Alleles
/
Toll-Like Receptors
/
Toll-Like Receptor 2
Limits:
Humans
/
Male
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2005
Type:
Article
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