Immunohistochemical Study Of The Vascular Endothelial Growth Factor (Vegf) Expression In Genistein Treated Hamster Buccal Pouch Oral Carcinoma Model
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 147-154, 2002.
Article
in Korean
| WPRIM
| ID: wpr-99494
ABSTRACT
Genistein that is a component of soy has been reported to have a protective effect on the carcinogenesis of various tumors and to inhibit the growth of a wide variety of tumor cell in vitro. Angiogenesis is an essential process for the carcinogenesis, growth, invasion and metastasis of cancer and genistein has been suggested to act as natural anti-angiogenic agent. The purpose of this study was to evaluate the effects of genistein on the vascular endothelial growth factor (VEGF) expression in hamster buccal pouch oral carcinogenesis model induced by 9, 10-dimethyl 1,2-benzanthracene (DMBA). Experimental group that were supplied with 0.1mg/day genistein were sacrificed by time schedules and routinely processed for immunohistochemical examination of VEGF. In genistein treated group, carcinogenesis was retarded with respect to the acanthosis, hyperkeratosis, and epithelial dysplasia. Immunohistochemical study showed that the VEGF protein of genistein group was less expressed than that of the control group. (p < 0.05) Thus, it is postulated that genistein has chemopreventive effect on the oral carcinogenesis, and this chemopreventive effect, at least partly, is originated from the anti-angiogenic effect of genistein
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Appointments and Schedules
/
Genistein
/
Vascular Endothelial Growth Factor A
/
Carcinogenesis
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2002
Type:
Article
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