Progress of ferroptosis in cancer metastasis / 肿瘤研究与临床

ABSTRACT

Ferroptosis is a newly discovered programmed death mode characterized by the accumulation of lipid peroxide and reactive oxygen species and the increase of free iron, which involves biological processes including glutathione metabolism, iron metabolism, lipid metabolism and oxidative stress. Tumor metastasis is an important feature of tumor malignancy and one of the main causes of recurrence and death in cancer patients. Recent studies have demonstrated that iron death is closely related to tumorigenesis and development and suggested that ferroptosis inducers are expected to be a new strategy for the treatment of cancer metastasis. This paper reviews the regulatory mechanisms related to ferroptosis and its role in the tumor metastasis, invasion, circulation and colonization.