Research progress on function of Septin / 中国生物制品学杂志

ABSTRACT

@#Septin is a highly conserved class of GTP-binding proteins found in eukaryotes other than higher plants.The different subtypes of Septin can form higher order structures such as filamentous or ring-like structures in the form of heterodimer to perform their functions,which can regulate physiological processes such as yeast budding and cell division,as well as participating in the defense response of the host cell.Abnormal expression or mutation of Septin is closely related to the occurrence and development of tumors and neurological diseases.This paper summarized the physiological functions of the Septin family,the effects of Septin on the occurrence and development of tumors and neurological diseases,and the role of Septin in the host immune response.