Pyridine pigments from functional Monascus rice / 药学学报
Acta Pharmaceutica Sinica
; (12): 2442-2447, 2023.
Article
in Zh
| WPRIM
| ID: wpr-999110
Responsible library:
WPRO
ABSTRACT
The trace chemical components in functional Monascus rice were studied to explore the potential bioactive substances. MCI column, Sephadex LH-20 gel, and preparative liquid chromatography were used to purified the ethyl acetate extract from functional Monascus rice. Two novel pyridine Monascus pigments were isolated and identified, named monascopyridine G (1) and monascopyridine H (2), respectively based on extensive mass spectrometry (MS), infrared radiation (IR), and nuclear magnetic resonance (NMR) analysis. The molecular docking experiments between compounds 1 and 2 and peroxisome proliferators-activated receptor-gamma (PPARγ) showed that they exhibited obvious binding force with the receptor protein. Besides, the biosynthetic pathways of the two compounds were proposed, which provide a valuable reference for the selective production of these potential bioactive substances.
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Index:
WPRIM
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2023
Type:
Article