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Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021.
Abu Jabal, Kamal; Ben-Amram, Hila; Beiruti, Karine; Batheesh, Yunis; Sussan, Christian; Zarka, Salman; Edelstein, Michael.
  • Abu Jabal K; Ziv Medical Centre, Safed, Israel.
  • Ben-Amram H; These authors contributed equally to this article and share first authorship.
  • Beiruti K; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Batheesh Y; Ziv Medical Centre, Safed, Israel.
  • Sussan C; These authors contributed equally to this article and share first authorship.
  • Zarka S; Ziv Medical Centre, Safed, Israel.
  • Edelstein M; Ziv Medical Centre, Safed, Israel.
Euro Surveill ; 26(6)2021 02.
Article in English | MEDLINE | ID: covidwho-1080354
ABSTRACT
The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunogenicity, Vaccine / COVID-19 Vaccines Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.6.2100096

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunogenicity, Vaccine / COVID-19 Vaccines Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.6.2100096