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Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of Viruses.
Mese, Kemal; Bunz, Oskar; Volkwein, Wolfram; Vemulapalli, Sahithya P B; Zhang, Wenli; Schellhorn, Sebastian; Heenemann, Kristin; Rueckner, Antje; Sing, Andreas; Vahlenkamp, Thomas W; Severing, Anna-Lena; Gao, Jian; Aydin, Malik; Jung, Dominik; Bachmann, Hagen S; Zänker, Kurt S; Busch, Ulrich; Baiker, Armin; Griesinger, Christian; Ehrhardt, Anja.
  • Mese K; Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, 58453 Witten, Germany.
  • Bunz O; Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, 58453 Witten, Germany.
  • Volkwein W; Department of Prosthodontics, School of Dentistry, Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany.
  • Vemulapalli SPB; Bavarian Health and Food Safety Authority (LGL), 85764 Oberschleissheim, Germany.
  • Zhang W; Department of NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
  • Schellhorn S; Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, 58453 Witten, Germany.
  • Heenemann K; Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, 58453 Witten, Germany.
  • Rueckner A; Center for Infectious Diseases, Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.
  • Sing A; Center for Infectious Diseases, Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.
  • Vahlenkamp TW; Bavarian Health and Food Safety Authority (LGL), 85764 Oberschleissheim, Germany.
  • Severing AL; Center for Infectious Diseases, Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.
  • Gao J; Centre for Biomedical Education and Research (ZBAF), Institute for Translational Wound Research, Witten/Herdecke University, 58453 Witten, Germany.
  • Aydin M; Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, 58453 Witten, Germany.
  • Jung D; Center for Child and Adolescent Medicine, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten/Herdecke University, 42283 Wuppertal, Germany.
  • Bachmann HS; Centre for Biomedical Education and Research, Institute of Pharmacology and Toxicology, Witten/Herdecke University, 58453 Witten, Germany.
  • Zänker KS; Centre for Biomedical Education and Research, Institute of Pharmacology and Toxicology, Witten/Herdecke University, 58453 Witten, Germany.
  • Busch U; Center for Biomedical Education and Research (ZBAF), Institute of Immunology, Witten/Herdecke University, 58453 Witten, Germany.
  • Baiker A; Bavarian Health and Food Safety Authority (LGL), 85764 Oberschleissheim, Germany.
  • Griesinger C; Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, 58453 Witten, Germany.
  • Ehrhardt A; Bavarian Health and Food Safety Authority (LGL), 85764 Oberschleissheim, Germany.
Int J Mol Sci ; 22(18)2021 Sep 17.
Article in English | MEDLINE | ID: covidwho-1430892
ABSTRACT
Previous studies reported on the broad-spectrum antiviral function of heparin. Here we investigated the antiviral function of magnesium-modified heparin and found that modified heparin displayed a significantly enhanced antiviral function against human adenovirus (HAdV) in immortalized and primary cells. Nuclear magnetic resonance analyses revealed a conformational change of heparin when complexed with magnesium. To broadly explore this discovery, we tested the antiviral function of modified heparin against herpes simplex virus type 1 (HSV-1) and found that the replication of HSV-1 was even further decreased compared to aciclovir. Moreover, we investigated the antiviral effect against the new severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and measured a 55-fold decreased viral load in the supernatant of infected cells associated with a 38-fold decrease in virus growth. The advantage of our modified heparin is an increased antiviral effect compared to regular heparin.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Heparin / Magnesium Chloride Type of study: Prognostic study Topics: Traditional medicine Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms221810075

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Heparin / Magnesium Chloride Type of study: Prognostic study Topics: Traditional medicine Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms221810075