What is the impact of microvascular complications of diabetes on severe COVID-19?
Microvasc Res
; 140: 104310, 2022 03.
Article
in English
| MEDLINE | ID: covidwho-1586954
ABSTRACT
Evidence suggests severe coronavirus disease-19 (COVID-19) infection is characterised by pulmonary and systemic microvasculature dysfunction, specifically, acute endothelial injury, hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in itself, confers an increased risk of adverse COVID-19 outcomes. It has been suggested that pre-existing endothelial dysfunction and microvascular disease in diabetes will exacerbate the vascular insults associated with COVID-19 and thus lead to increased severity of COVID-19 infection. In this article, we evaluate the current evidence exploring the impact of microvascular complications, in the form of diabetic retinopathy and nephropathy, in individuals with COVID-19 and diabetes. Future insights gained from exploring the microvascular injury patterns and clinical outcomes may come to influence care delivery algorithms for either of these conditions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Endothelium, Vascular
/
Thrombophilia
/
Diabetic Angiopathies
/
Pandemics
/
SARS-CoV-2
/
COVID-19
/
Microcirculation
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Microvasc Res
Year:
2022
Document Type:
Article
Affiliation country:
J.mvr.2021.104310
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