COVID-19-Related Stroke.
Transl Stroke Res
; 11(3): 322-325, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-186593
ABSTRACT
The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a "sepsis-induced coagulopathy" and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endothelial and smooth muscle cells. ACE2 is a key part of the renin angiotensin system (RAS) and a counterbalance to angiotensin-converting enzyme 1 (ACE1) and angiotensin II. Angiotensin II is proinflammatory, is vasoconstrictive, and promotes organ damage. Depletion of ACE2 by SARS-CoV-2 may tip the balance in favor of the "harmful" ACE1/angiotensin II axis and promote tissue injury including stroke. There is a rationale to continue to treat with tissue plasminogen activator for COVID-19-related stroke and low molecular weight heparinoids may reduce thrombosis and mortality in sepsis-induced coagulopathy.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Stroke
Type of study:
Observational study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Transl Stroke Res
Year:
2020
Document Type:
Article
Affiliation country:
S12975-020-00818-9
Similar
MEDLINE
...
LILACS
LIS