Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies.

Loesche, Michael; Karlson, Elizabeth W; Talabi, Opeyemi; Zhou, Guohai; Boutin, Natalie; Atchley, Rachel; Loevinsohn, Gideon; Chang, Jun Bai Park; Hasdianda, Mohammad A; Okenla, Adetoun; Sampson, Elizabeth; Schram, Haley; Magsipoc, Karen; Goodman, Kirsten; Donahue, Lauren; MacGowan, Maureen; Novack, Lewis A; Jarolim, Petr; Baden, Lindsey R; Nilles, Eric J

Loesche, Michael; Karlson, Elizabeth W; Talabi, Opeyemi; Zhou, Guohai; Boutin, Natalie; Atchley, Rachel; Loevinsohn, Gideon; Chang, Jun Bai Park; Hasdianda, Mohammad A; Okenla, Adetoun; Sampson, Elizabeth; Schram, Haley; Magsipoc, Karen; Goodman, Kirsten; Donahue, Lauren; MacGowan, Maureen; Novack, Lewis A; Jarolim, Petr; Baden, Lindsey R; Nilles, Eric J.

Emerg Infect Dis ; 28(9): 1859-1862, 2022 09.

Article in English | MEDLINE | ID: covidwho-1963356

ABSTRACT

ABSTRACT

Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies.

Subject(s)

COVID-19; SARS-CoV-2; Antibodies, Viral; COVID-19/epidemiology; Coronavirus Nucleocapsid Proteins/immunology; Humans; Kinetics; Nucleocapsid; Phosphoproteins/immunology; Seroepidemiologic Studies

Keywords

COVID-19; SARS-CoV-2; coronavirus disease; coronaviruses; kinetics; longitudinal; nucleocapsid antibody; respiratory infections; seroepidemiology; seroreversion; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Emerg Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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