SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice.
Emerg Infect Dis
; 28(11): 2352-2355, 2022 Nov.
Article
in English
| MEDLINE | ID: covidwho-2054901
ABSTRACT
We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.
Keywords
Australia; COVID-19; K18-hACE2 mice; Omicron BA.1; SARS-CoV-2; SARS-CoV-2 variants; ancestral; challenge; coronavirus disease; cross-protection; immunogenicity; mice; neutralizing antibodies; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine-preventable diseases; viruses; zoonoses
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Randomized controlled trials
Topics:
Variants
Limits:
Animals
Language:
English
Journal:
Emerg Infect Dis
Journal subject:
Communicable Diseases
Year:
2022
Document Type:
Article
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