Novel intraoperative near-infrared imaging strategy to identify abnormalities in the anterior mediastinum.
J Cardiothorac Surg
; 17(1): 302, 2022 Dec 09.
Article
in English
| MEDLINE | ID: covidwho-2162397
ABSTRACT
Thoracic surgeons are frequently asked to biopsy suspicious tissues in the anterior mediastinum to discriminate between a reactive versus malignant pathology such as lymph nodes. The most common benign cause of a mediastinal lymph node is a reactive lymph node from a prior infection or inflammatory process such as post-COVID or granulomatous disease. The most common malignant cause is a lymphoproliferative disorder but also metastatic disease from neck, breast and other regional cancers. Biopsies in this location are challenging because they are far from the trachea and the sternum is a barrier to most diagnostic procedures. Thus, a surgical biopsy is frequently required and a common procedure for Thoracic surgeons. Technically, identifying these lesions can be challenging, particularly for small lesions or those in patients with high body mass index. In order to improve contrast between diseased tissue in the anterior mediastinum and surrounding adipose tissue, we have been studying near-infrared imaging during surgery using indocyanine green (ICG) to give contrast to the abnormal tissues and to avoid an unnecessary extended resection. We developed a modified technique to give ICG to a patient during a biopsy in the anterior mediastinum to specifically highlight abnormal tissues. As a proof-of-principle, we present a case of a young woman with a suspicious 2 cm mediastinal lymph node that required surgical biopsy.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sentinel Lymph Node Biopsy
/
COVID-19
Type of study:
Case report
Topics:
Long Covid
Limits:
Female
/
Humans
Language:
English
Journal:
J Cardiothorac Surg
Year:
2022
Document Type:
Article
Affiliation country:
S13019-022-02054-8
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