Your browser doesn't support javascript.
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.
Pernet, Erwan; Sun, Sarah; Sarden, Nicole; Gona, Saideep; Nguyen, Angela; Khan, Nargis; Mawhinney, Martin; Tran, Kim A; Chronopoulos, Julia; Amberkar, Dnyandeo; Sadeghi, Mina; Grant, Alexandre; Wali, Shradha; Prevel, Renaud; Ding, Jun; Martin, James G; Thanabalasuriar, Ajitha; Yipp, Bryan G; Barreiro, Luis B; Divangahi, Maziar.
  • Pernet E; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada. Erwan.pernet@mail.mcgill.ca.
  • Sun S; Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.
  • Sarden N; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases and Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Gona S; Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.
  • Nguyen A; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases and Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Khan N; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
  • Mawhinney M; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
  • Tran KA; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
  • Chronopoulos J; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
  • Amberkar D; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
  • Sadeghi M; Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
  • Grant A; Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
  • Wali S; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
  • Prevel R; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
  • Ding J; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
  • Martin JG; McGill University Health Centre, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
  • Thanabalasuriar A; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
  • Yipp BG; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases and Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Barreiro LB; Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.
  • Divangahi M; Department of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.
Nature ; 614(7948): 530-538, 2023 02.
Article in English | MEDLINE | ID: covidwho-2185938
ABSTRACT
Resident-tissue macrophages (RTMs) arise from embryonic precursors1,2, yet the developmental signals that shape their longevity remain largely unknown. Here we demonstrate in mice genetically deficient in 12-lipoxygenase and 15-lipoxygenase (Alox15-/- mice) that neonatal neutrophil-derived 12-HETE is required for self-renewal and maintenance of alveolar macrophages (AMs) during lung development. Although the seeding and differentiation of AM progenitors remained intact, the absence of 12-HETE led to a significant reduction in AMs in adult lungs and enhanced senescence owing to increased prostaglandin E2 production. A compromised AM compartment resulted in increased susceptibility to acute lung injury induced by lipopolysaccharide and to pulmonary infections with influenza A virus or SARS-CoV-2. Our results highlight the complexity of prenatal RTM programming and reveal their dependency on in trans eicosanoid production by neutrophils for lifelong self-renewal.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Macrophages, Alveolar / 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Cell Self Renewal / Neutrophils Limits: Animals Language: English Journal: Nature Year: 2023 Document Type: Article Affiliation country: S41586-022-05660-7

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Macrophages, Alveolar / 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Cell Self Renewal / Neutrophils Limits: Animals Language: English Journal: Nature Year: 2023 Document Type: Article Affiliation country: S41586-022-05660-7