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O-GalNAc glycosylation affects the immunogenicity of the receptor-binding domain (RBD) of SARS-CoV-2 spike protein.
Rong, Yongheng; Wang, Xingyun; Mao, Weian; Chen, Min; Wang, Shengjun; Wang, Peng George; He, Yunjiao; Kong, Yun.
  • Rong Y; National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. kongyun@sdu.edu.cn.
  • Wang X; School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China. heyj@sustech.edu.cn.
  • Mao W; National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. kongyun@sdu.edu.cn.
  • Chen M; National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. kongyun@sdu.edu.cn.
  • Wang S; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266071, China.
  • Wang PG; School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China. heyj@sustech.edu.cn.
  • He Y; School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China. heyj@sustech.edu.cn.
  • Kong Y; National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. kongyun@sdu.edu.cn.
Chem Commun (Camb) ; 59(13): 1797-1800, 2023 Feb 09.
Article in English | MEDLINE | ID: covidwho-2221890
ABSTRACT
The spike protein of SARS-CoV-2 has been widely used as an effective vaccine immunogen, although some limitations still remain. Herein, O-GalNAc glycosylated RBD (Tn-RBD) was synthesized as an antigen via in vitro glycosylation reactions. The inhibition ability against hACE2 binding of antibodies induced with Tn-RBD was 30-40% increased compared to that induced with RBD. This result implies that Tn-glycosylation might play important roles in the immunogenicity of the RBD protein, which should be considered in the design of novel vaccines to fight against COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: D2cc06583e

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2023 Document Type: Article Affiliation country: D2cc06583e