Analysis of risk factors of fungal superinfections in viral pneumonia patients: A systematic review and meta-analysis.
Immun Inflamm Dis
; 11(1): e760, 2023 01.
Article
in English
| MEDLINE | ID: covidwho-2300913
ABSTRACT
BACKGROUND:
Infections with fungi, such as Aspergillus species, have been found as common complications of viral pneumonia. This study aims to determine the risk factors of fungal superinfections in viral pneumonia patients using meta-analysis.OBJECTIVE:
This study aims to determine the risk factors of fungal infection s in viral pneumonia patients using meta-analysis.METHODS:
We reviewed primary literature about fungal infection in viral pneumonia patients published between January 1, 2010 and September 30, 2020, in the Chinese Biomedical Literature, Chinese National Knowledge Infrastructure, Wanfang (China), Cochrane Central Library, Embase, PubMed, and Web of Science databases. These studies were subjected to an array of statistical analyses, including risk of bias and sensitivity analyses.RESULTS:
In this study, we found a statistically significant difference in the incidence of fungal infections in viral pneumonia patients that received corticosteroid treatment as compared to those without corticosteroid treatment (p < .00001). Additionally, regarding the severity of fungal infections, we observed significant higher incidence of invasive pulmonary aspergillosis (IPA) in patients with high Acute Physiology and Chronic Health Evaluation (APACHE) II scores (p < .001), tumors (p = .005), or immunocompromised patients (p < .0001).CONCLUSIONS:
Our research shows that corticosteroid treatment was an important risk factor for the development of fungal infection in patients with viral pneumonia. High APACHE II scores, tumors, and immunocompromised condition are also important risk factors of developing IPA. The diagnosis of fungal infection in viral pneumonia patients can be facilitated by early serum galactomannan (GM) testing, bronchoalveolar lavage fluid Aspergillus antigen testing, culture, and biopsy.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Superinfection
/
Invasive Pulmonary Aspergillosis
/
Neoplasms
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Immun Inflamm Dis
Year:
2023
Document Type:
Article
Affiliation country:
Iid3.760
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