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Elevation of Neurodegenerative Serum Biomarkers among Hospitalized COVID-19 Patients (preprint)
medrxiv; 2021.
Preprint
in English
| medRxiv | ID: ppzbmed-10.1101.2021.09.01.21262985
ABSTRACT
INTRODUCTIONOlder adults hospitalized with COVID-19 are susceptible to neurological complications, particularly encephalopathy, which may reflect age-related neurodegenerative processes. METHODSSerum total tau, ptau-181, GFAP, NFL, UCHL1, and amyloid-beta(A{beta}-40,42) were measured in hospitalized COVID-19 patients without a history of dementia, and compared among patients with or without encephalopathy, in-hospital death versus survival, and discharge home versus other dispositions using multivariable Cox proportional hazards regression analyses. RESULTSAmong 251 patients, admission serum ptau-181 and UCHL1 were significantly elevated in patients with encephalopathy (both P<0.05) and total tau, GFAP, and NFL were significantly lower in those discharged home(all P<0.05). These markers correlated significantly with severity of COVID illness. NFL, GFAP and UCH-L1 were significantly higher in hospitalized COVID patients than in non-COVID controls with mild cognitive impairment or Alzheimers disease(AD). DISCUSSIONAge-related neurodegenerative biomarkers were elevated to levels observed in AD and associated with encephalopathy and worse outcomes among hospitalized COVID-19 patients.
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Main subject:
Brain Diseases
/
Cognition Disorders
/
Neurodegenerative Diseases
/
Dementia
/
Alzheimer Disease
/
COVID-19
Language:
English
Year:
2021
Document Type:
Preprint
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