1.
Chem Pharm Bull (Tokyo)
; 55(2): 223-6, 2007 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17268092
RESUMO
Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83-94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-alpha production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.