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1.
Ann Rheum Dis ; 45(7): 534-8, 1986 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-3488713

RESUMO

Association of HLA-DR4/Dw4 with rheumatoid arthritis (RA) is well established, but conflicting data exist on a possible association with the severity of the disease, including its extra-articular manifestations. In order to investigate whether a subgroup of RA is preferentially associated with DR4, HLA typing was performed in two groups of patients with severe extra-articular manifestations (Felty's syndrome and histologically proved leucocytoclastic vasculitis), patients with severe joint destruction (seropositive and seronegative), a group with only mild joint destruction, and in healthy controls. The frequency of HLA-DR4 was significantly raised in all patient groups compared with that in healthy controls. The two groups with severe extra-articular manifestations, however, both had a DR4 frequency of 92%, which was significantly (p = 0.002) higher than the 62.7% found in the remaining patients. No significant differences were observed between severe or mild joint destruction and seropositivity or seronegativity in the groups without the above-mentioned extra-articular manifestations. From these data we concluded that DR4 is preferentially associated with severe extra-articular disease manifestations of RA. This observation provides an immunogenetic basis for the disease heterogeneity and for the immunological analogy between RA and leprosy.


Assuntos
Artrite Reumatoide/imunologia , Adulto , Idoso , Artrite Reumatoide/classificação , Síndrome de Felty/imunologia , Feminino , Antígeno HLA-DR4 , Antígenos de Histocompatibilidade Classe II/análise , Humanos , Masculino , Pessoa de Meia-Idade , Vasculite/imunologia
2.
Hum Immunol ; 4(4): 343-50, 1982 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-6811517

RESUMO

The relationship between HLA phenotype and leprosy classification was studied in 73 unrelated patients and 92 healthy controls from a mixed Negroid-Caucasoid population originating from Surinam, South America. Heterogeneity in the distribution of HLA-DR (but not A, B, and C) was detected between tuberculoid (TT* + BT*) leprosy and lepromatous (BL* + LL*) leprosy patients (p = 0.024). This heterogeneity appeared to be caused almost exclusively by DR3. Most significantly, the frequency of DR3 was increased among polar tuberculoid (TT) leprosy patients as compared to the rest of the patients (p = 0.0003). Compared with healthy controls the frequency of DR3 was increased among TT patients (p = 0.006), unchanged in BT patients, and decreased among lepromatous (BL + LL) patients (p = 0.027). These data indicate that in this population an DR3-associated factor controls the type of the disease that develops after infection with Mycobacterium leprae.


Assuntos
Genes MHC da Classe II , Genética Populacional , Hanseníase/genética , Antígenos Heterófilos/genética , Frequência do Gene , Antígenos HLA-DR , Teste de Histocompatibilidade , Humanos , Hanseníase/classificação , Hanseníase/epidemiologia , Fenótipo , Suriname
3.
Tissue Antigens ; 18(3): 189-94, 1981 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-7336423

RESUMO

A population study to test whether associations between HLA and sporadic--i.e. non-familial--tuberculoid leprosy exist was undertaken in a hyperendemic area in India. Since previous family studies in the same area had shown both non-random haplotype segregation in the family members affected with tuberculoid leprosy and the preferential segregation of HLA-DR2 into tuberculoid leprosy patients, an increased frequency of DR2 among the "sporadic" patients was expected. However, no heterogeneity for HLA was detected between patients and controls. These findings could indicate that tuberculoid leprosy is a heterogeneous disease with regard to genetic background.


Assuntos
Antígenos HLA/genética , Hanseníase/genética , Infecções por Mycobacterium não Tuberculosas/genética , Infecções por Mycobacterium/genética , Feminino , Frequência do Gene , Teste de Histocompatibilidade , Humanos , Índia , Masculino , Fenótipo
4.
J Infect Dis ; 141(6): 693-701, 1980 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-6156220

RESUMO

Families with multiple cases of leprosy were tested for HLA (histocompatibility leukocyte antigen)-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR2. Thirty-one non-HLA genetic markers were also examined for indications of non-HLA-linked genetic factors that might control susceptibility to tuberculoid leprosy. A significant (P = 0.002) preferential inheritance of HLA-DR2 by siblings affected with tuberculoid leprosy, but not by healthy siblings nor by siblings affected with lepromatous leprosy, was observed. In addition, combined family data showed a significant (P less than 0.0025) excess of identical HLA haplotypes inherited from healthy parents by siblings affected with tuberculoid leprosy. Segregation on non-HLA polymorphisms did not deviate significantly from what would have occured randomly. These data are compatible with a recessive inheritance of HLA-linked susceptibility to tuberculoid leprosy. The preferential segregation of DR2 observed in children with tuberculoid leprosy (P less than 0.001 for the combined data from India) indicates that the HLA-linked susceptibility gene is either DR2 or in linkage disequilibrium with it.


Assuntos
Epitopos/genética , Antígenos de Histocompatibilidade/genética , Hanseníase/genética , Tuberculose Cutânea/genética , Feminino , Marcadores Genéticos , Humanos , Hanseníase/classificação , Hanseníase/complicações , Hanseníase/imunologia , Complexo Principal de Histocompatibilidade , Masculino , Linhagem , Tuberculose Cutânea/complicações , Tuberculose Cutânea/imunologia
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