RESUMO
Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under conditions of chronic animal experiment.
Assuntos
Hansenostáticos/uso terapêutico , Hanseníase/tratamento farmacológico , Tiocarbamatos/uso terapêutico , Animais , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Hansenostáticos/sangue , Hanseníase/sangue , Hanseníase/mortalidade , Hanseníase/veterinária , Masculino , Camundongos , Camundongos Endogâmicos CBA , Viabilidade Microbiana/efeitos dos fármacos , Mycobacterium leprae/efeitos dos fármacos , Mycobacterium leprae/fisiologia , Tiocarbamatos/sangue , Tiocarbamatos/química , Resultado do TratamentoRESUMO
Effects of some dialkyldithiocarbamate derivatives on multiplication of M. leprae were studied in infected mice. Compounds significantly suppressing M. leprae proliferation were selected. By antibacterial activity one of these compounds was superior to dapsone, the main antileprosy drug.
Assuntos
Hansenostáticos/farmacologia , Hanseníase/tratamento farmacológico , Tiocarbamatos/farmacologia , Animais , Contagem de Colônia Microbiana , Dapsona/farmacologia , Avaliação Pré-Clínica de Medicamentos , Hanseníase/microbiologia , Camundongos , Camundongos Endogâmicos CBA , Mycobacterium leprae/efeitos dos fármacosRESUMO
We proposed a simple and economic method for determination of general toxic effects of drugs consisting in evaluation of serum morphology by polarization light microscopy.