Assuntos
Anti-Infecciosos Urinários/efeitos adversos , Eritema Nodoso/induzido quimicamente , Hanseníase Virchowiana/complicações , Ofloxacino/efeitos adversos , Dermatopatias Vesiculobolhosas/induzido quimicamente , Adolescente , Toxidermias/etiologia , Humanos , Hanseníase Virchowiana/tratamento farmacológico , Masculino , Infecções Urinárias/tratamento farmacológicoRESUMO
With the world's focus on reducing the leprosy patient load to the extent of elimination, finding and reporting the rarer presentations of leprosy becomes important for prompt treatment. Also, these untreated patients may serve as a potential source of infection in community. We report a 35-year old man diagnosed to have lepromatous leprosy and erythema nodosum leprosum with inguinal lymph node abscess and suspected cardiac involvement that proved fatal. We stress the importance of detailed workup to look for associated systemic involvement for timely intervention and favourable outcome.
Assuntos
Eritema Nodoso/diagnóstico , Coração/fisiopatologia , Hanseníase Virchowiana/diagnóstico , Linfonodos/patologia , Abscesso , Adulto , Eritema Nodoso/patologia , Eritema Nodoso/fisiopatologia , Humanos , Hanseníase Virchowiana/patologia , Hanseníase Virchowiana/fisiopatologia , MasculinoAssuntos
Neoplasias Faciais/diagnóstico , Neoplasias das Glândulas Sudoríparas/diagnóstico , Siringoma/diagnóstico , Neoplasias Vulvares/diagnóstico , Neoplasias Faciais/complicações , Feminino , Humanos , Neoplasias das Glândulas Sudoríparas/complicações , Siringoma/complicações , Neoplasias Vulvares/complicações , Adulto JovemRESUMO
Extramammary Paget's disease and Bowen's disease are histologically similar and immunohistochemistry is often required to make the diagnosis. We present a case of vulval Paget's disease with Bowen's disease in an elderly female. Strong positivity for cytokeratin 7, anti CAM 5.2, carcinoembryonic antigen (CEA) and periodic acid-Schiff (PAS) stain in clitoral, left labial and interface regions of the vulvectomy specimen confirmed the diagnosis of Paget's disease (PD) while positive staining for p63 in the right labial and interface regions helped in establishing the diagnosis of concurrent Bowen's disease (BD).
Assuntos
Doença de Bowen/patologia , Neoplasias Primárias Múltiplas/patologia , Doença de Paget Extramamária/patologia , Neoplasias Cutâneas/patologia , Neoplasias Vulvares/patologia , Biomarcadores/análise , Doença de Bowen/química , Doença de Bowen/cirurgia , Antígeno Carcinoembrionário/análise , Feminino , Humanos , Queratina-7/análise , Queratinas/análise , Proteínas de Membrana/análise , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/química , Neoplasias Primárias Múltiplas/cirurgia , Doença de Paget Extramamária/química , Doença de Paget Extramamária/cirurgia , Neoplasias Cutâneas/química , Neoplasias Cutâneas/cirurgia , Neoplasias Vulvares/química , Neoplasias Vulvares/cirurgiaRESUMO
Familial atrophia maculosa varioliformis cutis is a very rare disorder with less than 28 cases being reported in the literature worldwide and remains a mystery both as far as genetics and the virtue of its pathogenesis is concerned. We present a case of mother and son, both having this disorder with presentations unique in terms of sites involved and try to draw a five generations pedigree chart for the same. We further support its inheritance pattern as autosomal dominant. Also, we propose oral isotretinoin as an effective treatment modality for the same.
Assuntos
Dermatoses Faciais/genética , Dermatoses Faciais/patologia , Dermatopatias Genéticas/genética , Dermatopatias Genéticas/patologia , Adolescente , Adulto , Fármacos Dermatológicos/uso terapêutico , Epiderme/patologia , Dermatoses Faciais/tratamento farmacológico , Saúde da Família , Feminino , Genes Dominantes , Humanos , Índia , Isotretinoína/uso terapêutico , Masculino , Linhagem , Dermatopatias Genéticas/tratamento farmacológicoRESUMO
Phacomatosis cesioflammea is a rare condition defined by the simultaneous presence of both vascular and pigmentary nevus in the same patient. We report a case of a 4-year-old Indian female child who presented with diffuse dermal melanosis on the upper shoulders, upper anterior chest and lower back and extending to involve both sides of the arms and forearms, generalized port-wine stain on the back, shoulders and both upper limbs with sparing of the right palm. At places, the two types of lesions were superimposed on each other and were also present discretely on the back, but in close proximity to each other. There was the presence of melanosis bulbi on the right side of the eye. She was otherwise normal. She was clinically diagnosed as a case of phacomatosis pigmentovascularis cesioflammea. The nonallelic twin spotting phenomenon has been proposed in the pathogenesis of this disorder.