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1.
Indian J Lepr ; 73(2): 121-9, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11579648

RESUMO

This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72%). Adverse drug reactions were more common in female than male subjects (55% vs 45%; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks.


Assuntos
Anemia/epidemiologia , Doença Hepática Induzida por Substâncias e Drogas/epidemiologia , Hansenostáticos/efeitos adversos , Hanseníase/tratamento farmacológico , Metemoglobinemia/epidemiologia , Adolescente , Adulto , Anemia/induzido quimicamente , Criança , Clofazimina/efeitos adversos , Dapsona/efeitos adversos , Quimioterapia Combinada , Feminino , Humanos , Hansenostáticos/uso terapêutico , Masculino , Metemoglobinemia/induzido quimicamente , Pessoa de Meia-Idade , Estudos Retrospectivos , Rifampina/efeitos adversos , Rifampina/uso terapêutico
2.
s.l; s.n; 2001. 9 p. tab.
Não convencional em Inglês | Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, Sec. Est. Saúde SP | ID: biblio-1240971

RESUMO

This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72 per cent). Adverse drug reactions were more common in female than male subjects (55 per cent vs 45 per cent; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Anemia/epidemiologia , Anemia/induzido quimicamente , Clofazimina/efeitos adversos , Dapsona/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/epidemiologia , Estudos Retrospectivos , Hansenostáticos/efeitos adversos , Hansenostáticos/uso terapêutico , Hanseníase/tratamento farmacológico , Metemoglobinemia/epidemiologia , Metemoglobinemia/induzido quimicamente , Quimioterapia Combinada , Rifampina/efeitos adversos , Rifampina/uso terapêutico
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