Assuntos
Antifúngicos/farmacocinética , Fármacos Dermatológicos/farmacocinética , Isotretinoína/farmacocinética , Itraconazol/farmacocinética , Tinha/tratamento farmacológico , Tinha/metabolismo , Administração Oral , Antifúngicos/administração & dosagem , Fármacos Dermatológicos/administração & dosagem , Interações Medicamentosas/fisiologia , Quimioterapia Combinada , Humanos , Isotretinoína/administração & dosagem , Itraconazol/administração & dosagem , Resultado do TratamentoRESUMO
BACKGROUND: Erythema nodosum leprosum (ENL) classically presents as tender evanescent skin nodules involving extremities, trunk, and face but may appear at any site. Mucosal involvement in ENL is uncommon, and its occurrence over glans is extremely rare. METHOD: We describe two interesting cases of ENL involving the glans penis and prepuce with different presentations. RESULT: The first case had lepromatous leprosy with ENL with involvement of the glans penis in the form of a painful ulcer with necrotic slough. The second case had borderline lepromatous leprosy with ENL with involvement of glans in the form of a single painful nodule. Histopathology showed features of ENL, and Ziehl-Neelsen staining showed numerous acid fast bacilli. CONCLUSION: We should be aware of genital involvement of ENL, which is a rare presentation and needs to be differentiated from other conditions requiring a different management approach.
Assuntos
Eritema Nodoso/patologia , Hanseníase Virchowiana/patologia , Mycobacterium leprae/isolamento & purificação , Doenças do Pênis/microbiologia , Pênis/patologia , Adulto , Quimioterapia Combinada , Eritema Nodoso/diagnóstico , Eritema Nodoso/tratamento farmacológico , Seguimentos , Humanos , Imuno-Histoquímica , Hanseníase Virchowiana/diagnóstico , Hanseníase Virchowiana/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Doenças do Pênis/tratamento farmacológico , Doenças do Pênis/patologia , Medição de Risco , Estudos de Amostragem , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Cysticercosis, especially neurocysticercosis, is a major public health problem in India. We report an unusual case of disseminated cysticercosis with extensive infiltration of the skin, central nervous system, skeletal muscles, eye, lung, and heart. A patient with extensive cutaneous cysticercosis must be thoroughly investigated for widespread internal organ involvement.