1.
Comp Biochem Physiol C Comp Pharmacol Toxicol
; 83(2): 295-306, 1986.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2871992
RESUMO
Diamino diphenyl sulfone (DDS), a chemotherapeutic compound used in the treatment of leprosy, was studied with regard to its effects on the embryonic development of eggs from the sea urchin Lytechinus variegatus. DDS disturbs the normal development of fertilized eggs by interfering with the mitotic apparatus and producing spheroid-shaped bodies shown to be aster-like bodies by staining techniques. A typical colchicine effect (formation of kidney-shaped cells) was also demonstrated.