RESUMO
Nineteen, randomly selected male patients with lepromatous leprosy were evaluated electrophysiologically. All of these patients had long-standing disease and were treated with dapsone alone. There were statistically significant differences between the values obtained in this group of leprosy patients compared to 20 age-matched controls in auditory brain stem evoked potentials (ABEP). The findings are consistent with a pathologic process located mainly between the cochlear nucleus and the lateral lemniscus in the auditory brain stem pathways. It should be emphasized that our patients had long-standing disease which was treated with dapsone. ABEP could very well be different in leprosy patients diagnosed early and treated for relatively short periods with multidrug therapy. Brain stem evoked response audiometry may be useful for evaluating the possibility of brain stem involvement in leprosy.
Assuntos
Doenças Auditivas Centrais/diagnóstico , Hanseníase Virchowiana/diagnóstico , Adulto , Dapsona/uso terapêutico , Potenciais Evocados Auditivos do Tronco Encefálico , Humanos , Hansenostáticos/uso terapêutico , Hanseníase Virchowiana/tratamento farmacológico , Masculino , Pessoa de Meia-IdadeRESUMO
Thirty-six patients with leprosy and 12 sex- and age-matched controls were investigated for disorders of the audiovestibular system, and vertebral artery measurements were calculated using a color Doppler ultrasound technique. Sensorineural hearing loss found to be of cochlear origin was detected in 8 of the leprosy patients. Maximal flow velocity and mean flow velocity were measured, and the total vertebral artery flow was calculated by adding flows from the right and left sides. There was a significant reduction in the total maximal peak flow velocity of the vertebral artery of the lepromatous patients compared to the controls. Doppler sonography of the vertebral artery gave useful information about some pathology seen in lepromatous patients.
Assuntos
Perda Auditiva Neurossensorial/diagnóstico , Hanseníase Virchowiana/fisiopatologia , Hanseníase Tuberculoide/fisiopatologia , Ultrassonografia Doppler em Cores , Artéria Vertebral/fisiologia , Doenças Vestibulares/diagnóstico , Adulto , Feminino , Hemodinâmica/fisiologia , Humanos , Hanseníase Virchowiana/complicações , Hanseníase Tuberculoide/complicações , Masculino , Pessoa de Meia-Idade , Artéria Vertebral/diagnóstico por imagemRESUMO
Thirty-nine patients with leprosy and fifteen sex- and age-matched controls were investigated for disorders of the fifth and seventh cranial nerves and that of the audiovestibular system. Sensorineural hearing loss found to be of cochlear origin was detected in eight (22%) of the patients with leprosy compared to none in the control group (p > 0.05). Vestibular dysfunction was noted in four patients (11.1%) compared to none in the control group (p < or = 0.05). Two cases were found to have fifth nerve involvement and one (2.8%) had seventh nerve involvement. None in the control group had fifth or seventh nerve deficit.