RESUMO
We report a patient who developed acute renal failure following the ingestion of a hair-dye with a suicidal intent. He was managed by hemodialysis and other symptomatic measures. He developed generalized seizures and underwent MRI scan of the brain using gadolinium containing contrast material followed by development of bilateral and symmetrical thickening and induration of the skin over the extremities and verrucous papules and plaques over the lower back. Skin biopsy and immunohistochemistry showed typical features of nephrogenic fibrosing dermopathy as well as deposits of calcium. Successful management of renal failure resulted in clearing of all skin lesions except a small bony hard plate like area overt the left leg, the biopsy of which showed features of osseous metaplasia.
Assuntos
Injúria Renal Aguda/induzido quimicamente , Tinturas para Cabelo/intoxicação , Dermopatia Fibrosante Nefrogênica/induzido quimicamente , Tentativa de Suicídio , Humanos , Masculino , Dermopatia Fibrosante Nefrogênica/patologia , Pele/patologia , Adulto JovemRESUMO
A 53 year-old male diabetic presented with a month-old, painful ulcer with necrotic margins over the right thigh. Wound debridement was done twice and the ulcer showed recurrent growth of a white, cottony filamentous structure. Cutaneous mucormycosis was suspected and confirmed by histopathology and a culture isolate of Apophysomyces elegans . The patient was treated with liposomal amphotericin-B and itraconazole followed by partial thickness skin grafting, and then discharged after being prescribed posaconazole syrup for three weeks. Regular follow-up was done and during the last visit after six months following discharge, the ulcer was found to have healed well with no recurrence of the fungus.
Assuntos
Dermatomicoses/microbiologia , Mucormicose/microbiologia , Acidentes de Trânsito , Antifúngicos/uso terapêutico , Desbridamento , Dermatomicoses/etiologia , Dermatomicoses/terapia , Complicações do Diabetes , Quimioterapia Combinada , Humanos , Masculino , Pessoa de Meia-Idade , Mucorales/isolamento & purificação , Mucormicose/etiologia , Mucormicose/terapia , Recidiva , Pele/microbiologia , Transplante de Pele , Coxa da PernaRESUMO
Disseminated strongyloidiasis is a rare manifestation in patients on immunosuppressive drugs. We report two cases of fatal disseminated Strongyloides stercoralis infestation. The first was in a patient of pemphigus vulgaris who developed an exacerbation of symptoms, one year after diagnosis and was given intravenous dexamethasone and azathioprine and in the third week of hospitalization developed features of septicemia, respiratory failure and petechial hemorrhages which were proven to be due to disseminated strongyloidiasis. The second patient was diagnosed to have stage IV diffuse large cell type of non-Hodgkin lymphoma and after the second cycle of chemotherapy, developed generalized symptoms of septicemia, respiratory failure, purpuric macules and patches. This was also proven to be disseminated strongyloidiasis.