[Chronobiological aspects of the action of diaminodiphenylsulfone on hematological mice induces in summer and winter seasons ]. / Khronobiologicheskie aspekty vliianiia diaminodifenilsul'fona na gematologicheskie pokazateli u myshei v letnii i zimnii sezony goda.

Mice experiments were made to study effects of diaminodiphenylsulphone (DDS)--basic antileprous drug--on circadian rhythms of hemoglobin levels, counts of red cells and leukocytes. The time of the drug administration varied within the day while seasons of the year were two--winter and summer. Blood components were studied with unified methods. The results of the study showed that DDS has significant effects on the structure of circadian rhythms of the above blood components. These effects correlate with the season of the year and time of DDS administration.

[Use of tuftsin in experimental leprosy]. / Primenenie taftsina v éksperimental'noi leprologii.

The effect of tuftsin was studied in vivo using CBA mice infected with M. leprae by Shepard's technique and in vitro using macrophage-like cell line P. 388 (Co-cultivated with M. leprae) and the cultivated leproma tissue. It was found out that tuftsin acted as a stimulator of M. leprae multiplication in foot-pads of mice and as a prolongator of M. leprae survival in the cells of macrophage-like cell line P .388. It is concluded that using tuftsin might be useful in view of studying different aspects of experimental leprosy.

[The modelling of chronic infection (experimental leprosy) against a background of macrophagal immunodeficiency]. / Modelirovanie khronicheskoi infektsii (éksperimental'noi lepry) na fone makrofagal'nogo immunodefitsita.

The dynamics of mycobacterial multiplication was followed in mice with intraplantar leprosy infection and preinduced macrophage insufficiency. The characteristics of Shepard's model appeared to be similar to those of the method proposed by the authors including the susceptibility to the main antileprosy drugs. Peritoneal macrophages were cytochemically studied in the process of development of mononuclear phagocyte deficiency and experimental leprosy. It was concluded that the method proposed preserving all the merits of Shepard's model should allow one to shorten significantly the duration of testing potential drugs for their antileprosy activity.

[Reproduction of experimental leprous infection in mice with a preliminary modelling of failure of the mononuclear phagocyte system]. / Vosproizvedenie éksperimental'noi leproznoi infektsii u myshei s predvaritel'no modelirovannoi nedostatochnost'iu sistemy mononuklearnykh fagotsitov.

CBA mice with induced insufficiency of mononuclear phagocyte system (MNPS) were inoculated intraplantar with M. leprae in a dose of 1 X 10(4). A significantly accelerated multiplication of M. leprae was noted in the sites of inoculation with the development of a generalized infections process and appearance in 6 months after inoculation of lepromatous structures in spleen, liver and other internal organs as compared with the animals with unchanged MNPS. The data obtained suggest that insufficiency in macrophage component of cell-mediated immunity might underline the sensibility to leprosy infection.