Comparative immunological and histopathological study in fifty cases of mucosal/nonmucosal lichen planus.

Lichen planus is a common disorder and 40-50% of LP patients also reveal mucosal lesions. It is well known that mucosal LP lesions take very long to heal in comparison to cutaneous lesions. Rarely erosive mucosal LP can turn malignant. Both CMI and humoral immunity may play role in aetiopathogenesis of LP. Present study was conducted to study and compare CMI, Humoral Immunity, histopathology in mucosal and nonmucosal LP.

Clinicopathological correlation in 50 cases of erythroderma.

Fifty cases of erythroderma were studied clinically and histopathologically. Clinically 11 were of eczemas, 12 of psoriasis, 14 were drug-induced, 11 of idiopathic group and 1 each of pemphigus foliaceus (PF) and cogenital bullous ichthyosiform erythroderma (CBIE). Histopathologically 10 cases of psoriasis, 1 of PF and 1 of CBIE showed specific histopathology and therefore clinical histopathological correlation was possible only in 12 (24%) cases. Exact differentiation in erythroderma due to eczemas, drugs or idiopathic was not possible histopathologically.

Recurrent post-herpetic erythema multiforme, herpes labialis and secondary vitiligo in siblings.

Presence of recurrent herpes labialis with resultant secondary vitiligo associated with recurrent erythema multiforme further leading to depigmentation of skin in relation to target shaped maculopapular lesions in two real sisters was observed as a unique phenomenon which probably has not been reported earlier.

Recurrent herpes zoster in a child with SLE.

A 12-year-old girl had systemic lupus erythematosus (SLE) and type IV lupus nephritis since three-and-a-half years. She was treated with prednisolone and cyclophosphamide. She had first attack of herpes zoster (HZ) involving eighth and ninth thoracic segments on right side at the age of nine years. Second attack occurred on the same segments on same side at the age of twelve years. The second attack of herpes zoster was treated with oral acyclovir 400 mg five times a day for seven days plus analgesics and multi-vitamins. Most probably this is the first case of recurrent herpes zoster (RHZ) in a child in Indian literature.

Drug-induced pseudolymphoma syndrome.

Five cases of pseudolymphoma syndrome (PS) in children aged six to twelve years were observed after anticonvulsant drugs. In two cases PS was observed after ten days and in three after fifteen days of therapy with the offending drug. Three cases of PS were due to carbamazepine and had morbilliform rash and two cases due to phenobarbitone had erythroderma. All had fever, generalised lymphadenopathy and 4/5 had hepatosplenomegaly. Therapy with 15 mg prednisolone daily and withdrawal of the offending durg led to cure in 4/5 cases and one died due to congestive cardiac failure.