Assuntos
Granuloma/diagnóstico , Doenças Nasais/diagnóstico , Granuloma/microbiologia , Granuloma/patologia , Histoplasmose/diagnóstico , Humanos , Leishmaniose Cutânea/diagnóstico , Hanseníase Virchowiana/diagnóstico , Lúpus Vulgar/diagnóstico , Septo Nasal/microbiologia , Deformidades Adquiridas Nasais/microbiologia , Doenças Nasais/microbiologia , Doenças Nasais/parasitologia , Doenças Nasais/patologia , Rinoscleroma/diagnóstico , Rinosporidiose/diagnóstico , Rosácea/diagnóstico , Sarcoidose/diagnóstico , Tuberculose Cutânea/diagnósticoRESUMO
Pentoxifylline (PTX) is a methylxanthine derivative with a variety of anti-inflammatory effects. Currently, PTX is approved by the Food and Drug Administration for the treatment of intermittent claudication, but studies have shown that it has a variety of physiological effects at the cellular level, which may be important in treating a diverse group of diseases.
Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Pentoxifilina/uso terapêutico , Adulto , Animais , Anti-Inflamatórios não Esteroides/farmacocinética , Anti-Inflamatórios não Esteroides/farmacologia , Antifibrinolíticos/farmacocinética , Antifibrinolíticos/farmacologia , Antifibrinolíticos/uso terapêutico , Síndrome de Behçet/tratamento farmacológico , Criança , Pré-Escolar , Doença Enxerto-Hospedeiro/tratamento farmacológico , Infecções por HIV/tratamento farmacológico , Hemorreologia/efeitos dos fármacos , Humanos , Lactente , Leishmaniose Cutânea/tratamento farmacológico , Hanseníase/tratamento farmacológico , Camundongos , Camundongos Nus , Pentoxifilina/farmacocinética , Pentoxifilina/farmacologia , Inibidores de Fosfodiesterase/farmacocinética , Inibidores de Fosfodiesterase/farmacologia , Inibidores de Fosfodiesterase/uso terapêutico , Sarcoidose/tratamento farmacológico , Dermatopatias/tratamento farmacológico , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Doenças Vasculares/tratamento farmacológicoRESUMO
BACKGROUND: Permethrin, a pyrethroid insecticide, is not yet available in Iran and may be a useful substitute for the control of scabies in Iran. AIM: To compare the efficacy of topical lindane with topical permethrin in the treatment of scabies in a population in Iran. METHODS: In a double-blind, randomized study, all consecutive patients with scabies were randomized into two groups. One group and their family contacts received 1% lindane cream, and the other group and their family contacts were treated with topical 5% permethrin cream. Subsequently, patients were followed up at 2- and 4-week post-treatment. RESULTS: Of the 99 patients enrolled in the study, 47 patients received 1% lindane cream, and 52 patients were treated topically with 5% permethrin cream. Permethrin provided an improvement rate of 84.6% after two weeks, whereas lindane was effective only in 48.9% of patients. CONCLUSION: Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study, and it seems that it could be an alternative treatment.
Assuntos
Hexaclorocicloexano/administração & dosagem , Inseticidas/administração & dosagem , Permetrina/administração & dosagem , Administração Tópica , Adolescente , Adulto , Criança , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
We report a 33-year-old Iranian woman with widespread ulcerative lesions in the setting of lepromatous leprosy. We think that the sudden appearance of the characteristic necrotic lesions in the absence of fever and other systemic manifestation, and in accordance with epidermal necrosis and the presence of large numbers of AFB in the endothelium are all in favor of the diagnosis of Lucio's phenomenon for this patient. To our knowledge this is the first patient who may have had this phenomenon reported from the Middle East.