Assuntos
Edema/etiologia , Hiperemia/complicações , Úlcera da Perna/etiologia , Deficiência de Proteína C/complicações , Tromboembolia/complicações , Veia Cava Inferior/patologia , Abdome/irrigação sanguínea , Adulto , Edema/patologia , Humanos , Hiperemia/diagnóstico por imagem , Hiperemia/patologia , Úlcera da Perna/patologia , Masculino , Deficiência de Proteína C/patologia , Radiografia , Tromboembolia/diagnóstico por imagem , Tromboembolia/patologia , Veia Cava Inferior/diagnóstico por imagemRESUMO
BACKGROUND: Lucio's phenomenon is a rare leprosy reaction characterised by bizarrely-shaped, purpuric skin lesions and ulceration. It occurs in diffuse lepromatous leprosy and it is mainly reported in patients from Mexico and the Caribbean. CASE DESCRIPTION: We describe the case of a 90-year-old Aruban man with recurrent leg ulcers and flexion contractures of the lower extremities. Occurrence of Lucio's phenomenon led to a diagnosis of diffuse lepromatous leprosy. Presence of Mycobacterium leprae was demonstrated in skin, bone marrow and lymph nodes. CONCLUSION: Lucio's phenomenon led to a diagnosis of leprosy. Leprosy is still endemic in Aruba.
Assuntos
Úlcera da Perna/etiologia , Hanseníase Virchowiana/diagnóstico , Idoso de 80 Anos ou mais , Evolução Fatal , Humanos , Úlcera da Perna/diagnóstico , Úlcera da Perna/tratamento farmacológico , Úlcera da Perna/patologia , Hansenostáticos/uso terapêutico , Hanseníase Virchowiana/complicações , Hanseníase Virchowiana/tratamento farmacológico , Hanseníase Virchowiana/patologia , Masculino , Índias OcidentaisRESUMO
Mycobacterium ulcerans infection causes a skin disease known as Buruli ulcer (BU), a disorder manifested usually as a solitary and painless nodule or papule that progresses to massive necrotizing destruction and cutaneous ulceration. When healing occurs, it often results in disabling deformities. Buruli ulcer is considered the third most common mycobacterial disease in immunocompetent people, after tuberculosis and leprosy. Although the emergence of Buruli ulcer in Western African countries over the past decade has been dramatic, it has been scarcely reported in industrialized countries. We report a patient from Equatorial Guinea who was human immunodeficiency virus-positive, presenting aggressive and multifocal BU associated with an underlying destructive osteomyelitis, in which only an aggressive surgical approach yielded to a resolution of the disease. In a global world, with increasing migratory population fluxes, an increased awareness of dermatologists regarding the clinical, histopathological and microbiological features of BU is important in order to avoid significant delays in diagnosis and treatment.
Assuntos
Úlcera da Perna/microbiologia , Infecções por Mycobacterium não Tuberculosas/diagnóstico , Osteomielite/microbiologia , Adulto , Feminino , Soropositividade para HIV/complicações , Humanos , Úlcera da Perna/patologia , Infecções por Mycobacterium não Tuberculosas/microbiologia , Infecções por Mycobacterium não Tuberculosas/patologia , Mycobacterium ulcerans/isolamento & purificação , Osteomielite/complicações , Osteomielite/diagnóstico , Reação em Cadeia da PolimeraseRESUMO
We report 2 cases of Lucio's phenomenon, a rare, aggressive, occasionally fatal type 2 reaction occurring in the diffuse nonnodular type of lepromatous leprosy. The clinical diagnosis of Lucio's phenomenon is difficult, and there are no known predictive or prognostic factors. Despite institution of aggressive treatment after diagnosis, our 2 cases had fatal outcomes.
Assuntos
Úlcera da Perna/patologia , Hanseníase Virchowiana/patologia , Pele/patologia , Idoso , Progressão da Doença , Evolução Fatal , Humanos , Hanseníase Virchowiana/diagnóstico , Masculino , Pessoa de Meia-Idade , NecroseRESUMO
Twelve cases of carcinomata arising in Trophic ulcers of Leprosy are presented. Out of these, 10 were on the plantar surface more commonly on the proximal part of foot, one on lower leg and dorsum of foot, and one in an ulcer over the lateral malleolus. Almost all presented with infected growths and regional lymphadenopathy. Three cases presented with advanced disease with fungating inguinal nodes and were fatal. Nine cases underwent below knee amputation under antibiotic cover as a definitive treatment and the lymph nodes were kept under observation. Histologically, all were low grade squamous cell carcinomas. In most cases lymph nodes regressed after removal of primary and in one case lymph nodes were positive for malignancy. This study was conducted at Dr. Bandorawalla Leprosy Hospital, Kondhawa, Pune 22 from the year 1981 to 1987.
Assuntos
Carcinoma de Células Escamosas/patologia , Transformação Celular Neoplásica , Úlcera da Perna/patologia , Hanseníase Dimorfa/patologia , Neoplasias Cutâneas/patologia , Adulto , Idoso , Biópsia , Feminino , Doenças do Pé/patologia , Humanos , Úlcera da Perna/dietoterapia , Masculino , Pessoa de Meia-IdadeAssuntos
Medicina Tropical , Adulto , Anemia Falciforme/patologia , Doenças Mamárias/patologia , Linfoma de Burkitt/patologia , Criança , Dracunculíase/patologia , Feminino , Herniorrafia , Humanos , Úlcera da Perna/patologia , Hanseníase/patologia , Masculino , Neurofibromatose 1/patologia , Nigéria , Noma/patologia , Febre Tifoide/patologiaRESUMO
Six cases of epitheliomatous degeneration, among which five spino-cellulars and one baso-cellular, happened among leprosy patients showing sores, ulcerations and planter ulcers, are quoted in this study. Here, the authors underline the favorable part of the defects of cellular immunity for the leprous pathogenesis, and the need of using histological exams systematically when noticing any continued delay of cicatrisation. An immuno-stimulating medication should be used for any leprosy patient showing obstinate trophical troubles.