Assuntos
Dermoscopia , Hemangioma/patologia , Neoplasias Cutâneas/patologia , Abdome , Adulto , Feminino , Humanos , MasculinoRESUMO
Hansen's disease is a chronic infectious granulomatous disease with varied clinical presentation. In the postelimination era, histoid Hansen's disease is an important emerging lepromatous subset known to mimic varied dermatoses, thereby making clinical diagnosis difficult and often delayed. We report two cases of histoid Hansen's disease bereft of clinical cardinal signs of leprosy.
Assuntos
Doença Granulomatosa Crônica/diagnóstico , Doença Granulomatosa Crônica/microbiologia , Hanseníase/microbiologia , Abdome/microbiologia , Abdome/patologia , Adulto , Antituberculosos/uso terapêutico , Doença Granulomatosa Crônica/tratamento farmacológico , Humanos , Hanseníase/classificação , MasculinoRESUMO
We present a rare case report of a 28-year-old man with a five-month history of bizarre extensive erythematous plaques on the abdomen extending in a dermatomal fashion to the left upper back.
Assuntos
Hanseníase/diagnóstico , Abdome , Adulto , Humanos , Hanseníase/patologia , Masculino , Pele/patologiaAssuntos
Edema/etiologia , Hiperemia/complicações , Úlcera da Perna/etiologia , Deficiência de Proteína C/complicações , Tromboembolia/complicações , Veia Cava Inferior/patologia , Abdome/irrigação sanguínea , Adulto , Edema/patologia , Humanos , Hiperemia/diagnóstico por imagem , Hiperemia/patologia , Úlcera da Perna/patologia , Masculino , Deficiência de Proteína C/patologia , Radiografia , Tromboembolia/diagnóstico por imagem , Tromboembolia/patologia , Veia Cava Inferior/diagnóstico por imagemAssuntos
Humanos , Masculino , Pessoa de Meia-Idade , Dermatopatias , Face , Hanseníase , Região Lombossacral , Abdome , Granuloma , MacrófagosAssuntos
Abdome/patologia , Bochecha/patologia , Dermatoses Faciais/patologia , Granuloma/patologia , Adulto , Biópsia , Doença Crônica , Feminino , HumanosRESUMO
Although rare in occidental countries, leprosy is an endemic disease throughout the world. Physicians may encounter imported cases and thus need to be aware of this diagnosis. We here report a 41-year-old male patient from French West Indies who presented with nonspecific extensive skin lesions and a peripheral neuropathy. Skin biopsy examination led to the diagnosis of borderline lepromatous leprosy.
Assuntos
Hanseníase Dimorfa/diagnóstico , Nervo Musculocutâneo/microbiologia , Mycobacterium leprae/isolamento & purificação , Doenças do Sistema Nervoso Periférico/microbiologia , Doenças Raras/diagnóstico , Pele/microbiologia , Nervo Tibial/microbiologia , Abdome/microbiologia , Adulto , Antibióticos Antituberculose/uso terapêutico , Dorso/microbiologia , Biópsia , Quimioterapia Combinada , Guadalupe , Humanos , Hansenostáticos/uso terapêutico , Hanseníase Dimorfa/complicações , Hanseníase Dimorfa/tratamento farmacológico , Extremidade Inferior/microbiologia , Masculino , Doenças do Sistema Nervoso Periférico/diagnóstico , Doenças do Sistema Nervoso Periférico/tratamento farmacológico , Doenças Raras/complicações , Doenças Raras/tratamento farmacológico , Pele/patologia , Tórax/microbiologia , Resultado do TratamentoRESUMO
Ulcers with maculo-papular rash are an unusual presenting feature of leprosy. They occur as result of neuropathy, type-2 lepra reaction or Lucio's phenomenon. The hall mark of type-2 reaction is erythema nodosum. Very rarely it manifests as ulcerative skin lesions. We describe one such unusual case of a young male who presented with multiple ulcers and maculo-papular rash over the legs, chest and abdomen. In addition to this, he had fever, heart murmur, pulmonary infiltrates, neuropathy, and deranged liver function. A clinical differential diagnosis of infective endocarditis and systemic nectrozing vasculitis was made. Skin biopsy showed dense inflammation with lepra bacilli consistent with type-2 lepra reaction.
Assuntos
Hanseníase Virchowiana/complicações , Hanseníase Virchowiana/patologia , Dermatopatias/microbiologia , Dermatopatias/patologia , Úlcera/microbiologia , Úlcera/patologia , Abdome , Adulto , Antibacterianos/uso terapêutico , Diagnóstico Diferencial , Quimioterapia Combinada , Ecocardiografia , Endocardite Bacteriana/diagnóstico por imagem , Endocardite Bacteriana/tratamento farmacológico , Endocardite Bacteriana/microbiologia , Humanos , Perna (Membro) , Hansenostáticos/uso terapêutico , Hanseníase Virchowiana/tratamento farmacológico , Pneumopatias/diagnóstico por imagem , Pneumopatias/microbiologia , Masculino , Tórax , Tomografia Computadorizada por Raios XRESUMO
Porokeratosis is a specific disorder of keratinization that has five clinical types and shows a characteristic 'cornoid lamella' on histopathology. Malignant degeneration has been described in all forms of porokeratosis. To the best of our knowledge, this is the first Indian report of multicentric squamous cell carcinoma complicating porokeratosis.
Assuntos
Carcinoma de Células Escamosas/epidemiologia , Dermatoses da Mão/epidemiologia , Neoplasias Primárias Múltiplas/epidemiologia , Poroceratose/epidemiologia , Neoplasias Cutâneas/epidemiologia , Abdome , Adulto , Carcinoma de Células Escamosas/patologia , Comorbidade , Humanos , Masculino , Neoplasias Primárias Múltiplas/patologia , Neoplasias Cutâneas/patologia , Coxa da PernaRESUMO
BACKGROUND: Elephantiasis is a well-known condition in dermatology usually affecting the legs and external genitalia. It is characterized by chronic inflammation and obstruction of the lymphatic channels and by hypertrophy of the skin and subcutaneous tissues. The etiology is either idiopathic or caused by a variety of conditions such as chronic filarial disease, leprosy, leishmaniasis, and chronic recurrent cellulites. OBJECTIVE: Elephantiasis of the abdominal wall is very rare. A complete review of the English and French literature showed only two cases reported in 1966 and 1973, respectively. We report a third case of abdominal elephantiasis and we briefly review this entity. METHODS: We present the case of a 51-year-old woman who had progressively developed an enormous pediculated abdominal mass hanging down her knees. The skin was thickened, hyperpigmented, and fissured. She had a history of multiple abdominal cellulites. RESULTS: She underwent an abdominal lipectomy. Histopathology of the specimen confirmed the diagnosis of abdominal elephantiasis. CONCLUSION: Abdominal elephantiasis is a rare disease that represents end-stage failure of lymph drainage. Lipectomy should be considered in the management of this condition.
Assuntos
Elefantíase/cirurgia , Abdome , Feminino , Humanos , Lipectomia , Pessoa de Meia-IdadeAssuntos
Hanseníase Virchowiana/patologia , Mycobacterium leprae/crescimento & desenvolvimento , Abdome/microbiologia , Abdome/patologia , Humanos , Hanseníase Virchowiana/microbiologia , Região Lombossacral/microbiologia , Região Lombossacral/patologia , Masculino , Pessoa de Meia-Idade , Nervos Periféricos/patologia , Úlcera Cutânea/microbiologia , Úlcera Cutânea/patologiaRESUMO
The role of dosage of Mycobacterium leprae and the environment of the inoculated site, in producing leprosy lesions in immunologically-suppressed, highly-susceptible T900r mice, was investigated. Various doses of M. leprae, i.e., 10(7), 10(6), 10(5), 10(4), were inoculated into both flanks and footpads of two different groups of mice. The sites of inoculation were biopsied for histopathological examination and for M. leprae counts at the end of 6, 8 and 12 months. M. leprae multiplied at the infected site and disseminated [figure: see text] to other parts of the body at all concentrations in the mice that were infected in the footpad with a temperature of 31 degrees C. In animals inoculated at the flanks with a temperature of 37 degrees C, multiplication was recorded only when the dosage of M. leprae was high and there was no dissemination of the organism in any of them. The temperature at the site of entry and the dose of infecting M. leprae may play an important role in the development of leprosy in susceptible individuals exposed to M. leprae.
Assuntos
Abdome/microbiologia , Pé/microbiologia , Hanseníase/microbiologia , Mycobacterium leprae/fisiologia , Mycobacterium leprae/patogenicidade , Animais , Contagem de Colônia Microbiana , Modelos Animais de Doenças , Terapia de Imunossupressão , Hanseníase/fisiopatologia , Camundongos , Camundongos Endogâmicos CBA , Pele/microbiologia , Timectomia , Irradiação Corporal TotalRESUMO
BACKGROUND: Leprosy is a chronic systemic infection caused by the bacillus Mycobacterium leprae. Cutaneous neoplasms have been observed in patients with leprosy. Also, albeit less commonly, M. leprae have been documented in the lesions of skin cancer. OBJECTIVE: To describe a 62-year-old man with chronic sun exposure and exposure to armadillos who subsequently developed lepromatous leprosy, to discuss the cutaneous malignancies that have occurred in patients with leprosy, and to review the literature concerning the concurrent presence of an infectious pathogen and a cutaneous neoplasm in the same lesion. METHODS: Our patient's basal cell carcinomas were excised, his abdominal plaques were biopsied, and his leprosy infection was treated with dapsone and rifampin. The types of cutaneous malignancies in leprosy patients and infectious pathogens concurrently found in lesions of skin tumors were summarized after evaluating previously published reports. RESULTS: Skin biopsies from our patient demonstrated M. leprae bacilli not only in his abdominal plaques, but also in all of his basal cell carcinoma lesions. Fungal, mycobacterial, and viral pathogens have concurrently been observed in skin lesions of basal cell carcinomas, Kaposi's sarcoma, melanoma, mycosis fungoides, and squamous cell carcinoma. CONCLUSION: Patients with leprosy can develop skin cancers and the histologic interpretation of those skin cancers can show evidence of leprosy. It is uncertain to what degree the decreased cell-mediated immunity in patients with lepromatous leprosy either enhances their susceptibility to and/or influences the course of their cutaneous neoplasms; also, in these patients, the coexistence of M. leprae organisms and cutaneous malignancy in the same lesion is likely to be secondary to the high bacillary load that is present.