Assuntos
Acantólise/genética , Acantólise/patologia , Hiperpigmentação/genética , Hiperpigmentação/patologia , Dermatopatias Genéticas/genética , Dermatopatias Genéticas/patologia , Dermatopatias Papuloescamosas/genética , Dermatopatias Papuloescamosas/patologia , Acantólise/complicações , Acantólise/diagnóstico , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Hiperpigmentação/complicações , Pessoa de Meia-Idade , Linhagem , Dermatopatias Genéticas/complicações , Dermatopatias Papuloescamosas/complicaçõesRESUMO
Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders. Although a well-known concept, the student often has to refer to many sources to comprehend acantholysis completely. Thorough knowledge of this topic helps in clinching many diagnoses. The etiopathogenesis, classification, clinical signs, and laboratory demonstration of acantholysis are discussed in detail to help students build clear concepts. We have focused on various distinguishing points in different disorders for an easy grasp of the topic.
Assuntos
Acantólise/patologia , Acantólise/classificação , Acantólise/etiologia , Diagnóstico Diferencial , Humanos , Dermatopatias/classificação , Dermatopatias/etiologia , Dermatopatias/patologiaAssuntos
Acantólise/patologia , Vesícula/patologia , Pênfigo/patologia , Pele/patologia , Artefatos , Biópsia , HumanosRESUMO
Linear acantholytic dermatoses are a spectrum of cutaneous disorders that form a subset of linear dermatoses with distinct clinical features and histopathologically show acantholysis. The lesions may be zosteriform or follow the lines of Blaschko. This report describes a four-year-old boy who, on a follow up of two years, exhibited a relapsing acantholytic dermatosis along the lines of Blaschko. Histopathology of a representative lesion revealed epidermal acantholysis with multiple acantholytic keratinocytes with in the prickle cell layer and an absence of corp ronds and grains, consistent with features of Hailey-Hailey disease. This, to our knowledge, is the third case of relapsing linear acantholytic dermatosis reported.
Assuntos
Acantólise/patologia , Acantólise/metabolismo , Pré-Escolar , Humanos , Queratinócitos/metabolismo , Masculino , RecidivaRESUMO
An invisible dermatosis is defined as a skin disease manifesting no clinically apparent lesion but histologic changes of a characteristic nature. An example of an invisible form of transient acantholytic dermatosis is presented. Invisible forms of pseudoxanthoma elasticum, sarcoidosis, lepromatous leprosy, and lichen planus are reviewed. Dermal deposits may also be found on biopsy of clinically normal skin in amyloidosis, Hunter's and Hurler's syndromes, and thyroid disease.