RESUMO
Primary cutaneous cribriform apocrine carcinoma is a rare but distinct variant of primary cutaneous apocrine carcinoma and it is considered a low grade malignancy. We herein present a case of primary cutaneous cribriform apocrine carcinoma at the neck of a 26-year-old female. The tumor features a relatively well-circumscribed border and multiple aggregations of mildly pleomorphic epithelial cells with large ovoid nuclei, small nucleoli and abundant eosinophilic cytoplasms. Cribriform and tubular structures are the major architectural patterns. The primary differential diagnosis is cutaneous metastasis from a cribriform visceral carcinoma; others include primary secretory carcinoma of the skin, adenoid cystic basal cell carcinoma and primary cutaneous adenoid cystic carcinoma.
Assuntos
Adenocarcinoma/diagnóstico , Glândulas Apócrinas/patologia , Neoplasias das Glândulas Sudoríparas/diagnóstico , Adenocarcinoma/complicações , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias das Glândulas Sudoríparas/complicaçõesRESUMO
We report a case with abdominal complications of clofazimine treatment which included blackish discolouration of the lymph nodes, omentum and peritoneum. A 44-year-old female with lepromatous leprosy and a history of adverse reaction to clofazimine 2 years previously, presented with rectosigmoid junction adenocarcinoma. Laparotomy revealed an inoperable tumour with pigmentation of the bowel, serosa and peritoneum. A second operation had o be performed for transverse loop colostomy and a mesenteric lymph node biopsy sent for frozen section showed typical clofazimine crystals. Despite widespread use for many years in the treatment of leprosy, this drug is not known to be carcinogenic and this case provides no evidence for an association or link between its use and the patient's cancer. Apart from its use in leprosy, clofazimine may be used in the treatment of disseminated Mycobacterium avium-intracellulare infection, Buruli ulcer due to M. ulcerans and occasionally in other mycobacterial infections. An awareness of the rare side-effect described above may help in the clinical assessment and management of such cases, including the avoidance of unnecessary laparotomy.
Assuntos
Dor Abdominal/induzido quimicamente , Adenocarcinoma/complicações , Clofazimina/efeitos adversos , Neoplasias do Colo/complicações , Histiocitose/induzido quimicamente , Hansenostáticos/efeitos adversos , Hanseníase Virchowiana/complicações , Dor Abdominal/diagnóstico , Adulto , Cristalização , Feminino , Histiocitose/diagnóstico , Humanos , Hanseníase Virchowiana/tratamento farmacológicoRESUMO
The authors report a case of lepromatous leprosy associated with dermatopolymyositis and gastric adenocarcinoma. The literature is reviewed and the authors discuss about this association.