RESUMO
Lacaziosis, formerly called as lobomycosis, is a zoonotic mycosis, caused by Lacazia loboi, found in humans and dolphins, and is endemic in the countries on the Atlantic Ocean, Indian Ocean and Pacific Ocean of Japanese coast. Susceptible Cetacean species include the bottlenose dolphin (Tursiops truncatus), the Indian Ocean bottlenose dolphin (T. aduncus), and the estuarine dolphin (Sotalia guianensis); however, no cases have been recorded in other Cetacean species. We diagnosed a case of Lacaziosis in a Pacific white-sided dolphin (Lagenorhynchus obliquidens) nursing in an aquarium in Japan. The dolphin was a female estimated to be more than 14 years old at the end of June 2015 and was captured in a coast of Japan Sea in 2001. Multiple, lobose, and solid granulomatous lesions with or without ulcers appeared on her jaw, back, flipper and fluke skin, in July 2014. The granulomatous skin lesions from the present case were similar to those of our previous cases. Multiple budding and chains of round yeast cells were detected in the biopsied samples. The partial sequence of 43-kDa glycoprotein coding gene confirmed by a nested PCR and sequencing, which revealed a different genotype from both Amazonian and Japanese lacaziosis in bottlenose dolphins, and was 99 % identical to those derived from Paracoccidioides brasiliensis; a sister fungal species to L. loboi. This is the first case of lacaziosis in Pacific white-sided dolphin.
Assuntos
Antígenos de Fungos/genética , Golfinhos , Proteínas Fúngicas/genética , Glicoproteínas/genética , Lacazia/isolamento & purificação , Lobomicose/veterinária , Saccharomycetales/isolamento & purificação , Animais , Animais de Zoológico , Biópsia , Feminino , Histocitoquímica , Japão , Arcada Osseodentária/patologia , Lacazia/classificação , Lacazia/genética , Lobomicose/microbiologia , Lobomicose/patologia , Pulmão/diagnóstico por imagem , Pulmão/patologia , Microscopia , Reação em Cadeia da Polimerase , Radiografia Torácica , Saccharomycetales/classificação , Saccharomycetales/genética , Análise de Sequência de DNA , Homologia de Sequência , Pele/patologiaAssuntos
Hanseníase Virchowiana/complicações , Hanseníase Virchowiana/fisiopatologia , Doenças do Sistema Nervoso Periférico/etiologia , Biópsia , Diagnóstico Diferencial , Pé/patologia , Mãos/patologia , Humanos , Hipestesia/etiologia , Arcada Osseodentária/patologia , Hanseníase Virchowiana/patologia , Masculino , Pessoa de Meia-Idade , Condução Nervosa , Doenças do Sistema Nervoso Periférico/patologia , Sensação , Nervo Sural/patologiaAssuntos
Ossos Faciais/diagnóstico por imagem , Arcada Osseodentária/diagnóstico por imagem , Hanseníase/diagnóstico por imagem , Adolescente , Adulto , Criança , Pré-Escolar , Ossos Faciais/patologia , Feminino , Humanos , Arcada Osseodentária/patologia , Hanseníase/patologia , Masculino , Níger , Osteólise/patologia , Osteoporose/patologia , RadiografiaRESUMO
A brief review is presented of the Danish medieval skeletons with leprosy changes, particularly in the skulls, where the pathologic specific changes found are termed facies leprosa. The clinical aspect of facies leprosa is termed Bergen Syndrome I (nasal leprosy) and Bergen Syndrome II (the leprogenic changes of the alveolar process of the maxilla superior with loosening and/or loss of the frontal incisors). An account is given of the interim result of a clinical examination of 333 inpatients at the Prapradaeng Leprosarium in Bangkok, Thailand. In the group of 258 patients with lepromatous leprosy, 62.4% presented Bergen Syndrome I and 16.3% Bergen Syndrome II. These proportions differ clearly from the corresponding ratio found in the Danish medieval skulls.