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1.
Artigo em Inglês | MEDLINE | ID: mdl-33580925

RESUMO

Darier disease (DD) is a rare type of inherited keratinizing disorder with no definitive therapeutic approach. The objective of this study is to provide a detailed literature review of all the available treatment modalities of Darier disease, including those that are both surgical and non surgical, to compare their efficacies and to propose a novel therapeutic approach. A complete search of the literature for all articles describing the different treatments of Darier disease, with no restrictions on patients' ages, gender or nationalities, was performed with the use of PubMed. A total of 68 articles were included in the study: 3 prospective studies, 44 case reports/case series and 21 letters/correspondences/clinical images. The treatments described were topical, oral or physical. Retinoids (isotretinoin, tazarotene and adapalene) and fluorouracil were the two most effective topical treatments. Oral retinoids were the most effective oral therapy and were prescribed in the cases of generalized Darier disease. For localized and resistant skin lesions, physical therapies including surgical excision, dermabrasion and CO2 laser ablation were the first line choices. Limitations of this article include the inability to verify the accuracy of the published data, the relatively small sample size, the absence of randomized controlled clinical trials and possible unidentified confounding factors in various studies. In every therapeutic approach to Darier disease, consideration of patient comorbidities, disease distribution, severity and treatment accessibility is essential. Large and randomized clinical trials are necessary for the comparison of the efficacy and the safety of all the treatments of Darier disease and settling a consensus for management.


Assuntos
Doença de Darier/terapia , Administração Tópica , Algoritmos , Toxinas Botulínicas , Cetirizina/uso terapêutico , Ciclosporina/uso terapêutico , Dermabrasão , Diclofenaco/uso terapêutico , Di-Hidroxicolecalciferóis/uso terapêutico , Doxiciclina/uso terapêutico , Combinação de Medicamentos , Eletrocirurgia , Etinilestradiol/uso terapêutico , Ácidos Graxos/uso terapêutico , Fluoruracila/uso terapêutico , Glucocorticoides/uso terapêutico , Humanos , Lasers , Levanogestrel/uso terapêutico , Cloreto de Magnésio/uso terapêutico , Naltrexona/uso terapêutico , Fotoquimioterapia , Retinoides/uso terapêutico , Tacrolimo/uso terapêutico
2.
Br J Dermatol ; 134(3): 469-74, 1996 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8731671

RESUMO

We report three South African black teenage girls with extensive pruritic papular lesions arising on a pachydermatous base, resembling severe atopic dermatitis or onchodermatitis. All three had peculiar hypertrophic genital lesions and peripheral blood eosinophilia. Histological studies showed an eosinophil-rich lymphohistiocytic infiltrate and variable fibrosis. Extensive fibrillar extracellular deposition of eosinophil granule major basic protein was demonstrated by an indirect immunofluorescence technique. A beneficial therapeutic effect was obtained using dapsone, prednisolone and cetirizine. The term pachydermatous eosinophilic dermatitis is proposed and its position among other conditions characterized by peripheral blood and skin tissue eosinophilia, is discussed.


Assuntos
Dermatite/patologia , Eosinofilia/patologia , Adolescente , Anti-Inflamatórios/uso terapêutico , Cetirizina/uso terapêutico , Criança , Dapsona/uso terapêutico , Dermatite/tratamento farmacológico , Dermatite/imunologia , Quimioterapia Combinada , Eosinofilia/tratamento farmacológico , Eosinofilia/imunologia , Feminino , Genitália Feminina/patologia , Antagonistas dos Receptores Histamínicos H1/uso terapêutico , Humanos , Hansenostáticos/uso terapêutico , Prednisolona/uso terapêutico
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