Chance, the prepared mind and children with Hansen's disease.

1. Hansen's Disease is a chronic disease found in every continent in the world and among all ethnic groups. 2. Hawaii is neither a "hotbed" of the disease nor a place where the disease is absent. 3. Hansen's Disease is endemic in these islands, but we also have problems and resources for coping with it. 4. Current treatment approaches to clinical and public health aspects of the disease now offer hope. 5. There is a continuing need to educate patients, families, communities and professional workers in the many aspects of this disease. 6. Opportunity exists for Hawaii to become the training nucleus for medical and public health approaches to Hansen's Disease among the populations of the Pacific Basin.

Geographical variations in the occurrence of leprosy: possible roles played by nutrition and some other environmental factors.

The considerable variation in leprosy prevalence among 35 villages and field areas in South India was compared with variations in their socioeconomic and nutritional conditions. Using villages/field areas and aggregates thereof as observational units, leprosy prevalence rates were found to be significantly lower in field areas than in villages. Moreover, there was a significant correlation between the occurrence of malnutrition in children 1 to 4 years of age and the prevalence of leprosy. The possible association between the occurrence of malnutrition in childhood and leprosy is discussed in light of the present knowledge of leprosy, immunocompetence, and malnutrition. Strategies for further illumination of the hypothesized importance of malnutrition among children are discussed.

Peripheral arteriographic studies in leprosy.

There is a considerable controversy regarding the frequency and significance of vascular lesions in leprosy. Twenty-six cases of leprosy below the age of 40 years, without any local or systemic arterial disease and normal looking hands were subjected to brachial arteriography. One patient had posterior tibial arteriography also. The diagnosis of leprosy was confirmed by histology or bacteriological staining techniques. Biopsy material was studied from the involved areas and similar material was obtained from nine matched control subjects at autopsy. Skin thermometry and reflex vasodilatation was studied in eight cases. Arteriographic abnormalities such as occlusion, narrowing, tortuosity, dilatation, irregularity and incomplete filling were seen in more than two vessels in the hand in 50%, and in the digits in 75% of the cases. The ulnar artery was more frequently involved than the radial. Superficial and deep palmar arches were equally affected. Marked increase in arcuate vessels was noticed in nearly three-quarters of the patients, and in some, arcuate vessles were serving as collaterals. Histologically all sizes of vessles, including the capillaries, showed changes in nearly half the cases. Reflex vasodilation was lost in three cases of dimorphous leprosy and impaired or absent in three out of five cases of lepromatous leprosy. There was no predilection for any form of leprosy to show arterial changes more than the other. This study clearly demonstrates that the arterial involvement in leprosy is very frequent and must be playing an important role in causing mutilation and deformities of hands and feet.