RESUMO
BACKGROUND: Dapsone hypersensitivity syndrome (DHS) is a potentially life-threatening adverse drug reaction consisting of fever, hepatitis, exfoliative dermatitis, lymphadenopathy and hemolytic anemia. The incidence of DHS is estimated to be 2% in leprosy patients. Because the incidence of this drug eruption may be different in different ethnicities and diseases, we thought to investigate the incidence of DHS in non-leprosy patients. METHODS: This is a retrospective study to examine the incidence, clinical manifestations and prognosis of DHS in non-leprosy patients who were given dapsone at the National Taiwan University Hospital between June 2001 and December 2005. RESULTS: The incidence of DHS among non-leprosy patients was 1.66%. These patients ran a relatively benign course as compared with leprosy patients. CONCLUSION: The incidence of DHS among non-leprosy patients was compatible to that observed among leprosy patients. DHS in non-leprosy patients runs a favorable course with low morbidity in our study.
Assuntos
Dapsona/efeitos adversos , Hipersensibilidade a Drogas/etiologia , Hospitais de Ensino , Hansenostáticos/efeitos adversos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anemia Hemolítica/induzido quimicamente , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Criança , Pré-Escolar , Dapsona/administração & dosagem , Dermatite Esfoliativa/induzido quimicamente , Hipersensibilidade a Drogas/complicações , Hipersensibilidade a Drogas/tratamento farmacológico , Hipersensibilidade a Drogas/epidemiologia , Feminino , Febre/induzido quimicamente , Humanos , Incidência , Pacientes Internados/estatística & dados numéricos , Hansenostáticos/administração & dosagem , Doenças Linfáticas/induzido quimicamente , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Dermatopatias/tratamento farmacológico , Síndrome , Taiwan/epidemiologiaRESUMO
The authors report 3 cases of temporary generalized lymphoadenopathy directly related to Lamprene (Clofazimine) consumption. It appears that this side effect has never been reported in the literature.
Assuntos
Clofazimina/efeitos adversos , Hanseníase/tratamento farmacológico , Doenças Linfáticas/induzido quimicamente , Clofazimina/uso terapêutico , Feminino , Humanos , MasculinoRESUMO
The authors report a case of enteropathy due to clofazimine treatment for prurigo nodularis. The drug usually restricted to the treatment of leprosy has sometime been given to patients suffering from skin diseases because of its assumed anti-inflammatory effects. When high dosage of clofazimine treatment is carried on during a long period, and drug accumulates in the tissues and precipitates as a solid. This crystal storage in the lamina propria of the jejunal mucosa and in the mesenteric lymph nodes accounts for an enteropathy, sometime severe but slowly regressing after drug withdrawal. The electron microscopic study shows the prints of these crystals in autophagic vacuoles of histiocytes.
Assuntos
Clofazimina/efeitos adversos , Doenças do Jejuno/induzido quimicamente , Doenças Linfáticas/induzido quimicamente , Clofazimina/uso terapêutico , Feminino , Humanos , Doenças do Jejuno/patologia , Linfonodos/ultraestrutura , Doenças Linfáticas/patologia , Mesentério/patologia , Microscopia Eletrônica , Pessoa de Meia-Idade , Dermatopatias/tratamento farmacológicoRESUMO
A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this sulfone syndrome, an uncommon, potentially serious, side effect of dapsone therapy.