RESUMO
Leprosy, or Hansen's disease (HD), is caused by the bacterium Mycobacterium leprae and is a significant cause of morbidity worldwide. Clinical manifestations range from isolated skin rash to severe peripheral neuropathy. Treatment involves a prolonged course of multiple antimicrobials. Although rare in the U.S., with only 168 new cases reported in 2016, HD remains a prevalent disease throughout the world, with 214,783 new cases worldwide that same year.1 It remains clinically relevant for service members born in and deployed to endemic regions. This report describes a case of HD diagnosed in an active duty soldier born and raised in Micronesia, a highly endemic region.
Assuntos
Hanseníase/patologia , Militares/estatística & dados numéricos , Mycobacterium leprae , Doenças Profissionais/patologia , Úlcera Cutânea/patologia , Humanos , Hanseníase/epidemiologia , Hanseníase/microbiologia , Masculino , Micronésia/epidemiologia , Doenças Profissionais/epidemiologia , Doenças Profissionais/microbiologia , Úlcera Cutânea/microbiologia , Estados Unidos/epidemiologia , Adulto JovemRESUMO
A serologic survey was conducted to evaluate the prevalence of Mycobacterium leprae infection among healthcare workers and associated factors. Of 280 workers, 26 (9.3%) were positive using immunoglobulin M serology for PGL-I M. leprae antigen. Exposure to leprosy patients in the workplace was significantly associated with seropositivity (P=.044).
Assuntos
Infecção Hospitalar/epidemiologia , Infecção Hospitalar/microbiologia , Hanseníase/epidemiologia , Hanseníase/transmissão , Doenças Profissionais/epidemiologia , Doenças Profissionais/microbiologia , Adulto , Brasil/epidemiologia , Infecção Hospitalar/transmissão , Doenças Endêmicas , Ensaio de Imunoadsorção Enzimática , Feminino , Pessoal de Saúde , Inquéritos Epidemiológicos , Hospitais de Ensino , Humanos , Imunoglobulina M , Hanseníase/sangue , Masculino , Pessoa de Meia-Idade , Mycobacterium leprae/imunologia , Doenças Profissionais/sangue , PrevalênciaRESUMO
Analysis of cell-mediated immunity [(CMI) as judged from the Mantoux, Fernandez, and Mitsuda reactions and the presence of granulomas in biopsy material] against humoral immunity (measurements of anti-PGL-I, PGL-Tb1, and SL-IV IgG and IgM antibody titers by ELISA) were performed in selected human populations. The investigations yielded data indicating that humoral (B-cell) responses preceded protective CMI in both tuberculosis and leprosy. The B-cell responses were unrelated to (unfavorable) cell-mediated delayed-type hypersensitivity (DTH). Notwithstanding the difficulty in inferring sequential events from studies in humans, it was shown that in humoral responses there was an initial rise of specific IgM immunoglobulins that switched afterward to IgG production during subclinical tuberculosis and leprosy infections. In patent tuberculosis disease the IgM-to-IgG switch was observed in the majority of patients; in patent leprosy disease the switch was impaired in the majority of patients. The clinical, immunological, and laboratory data indicated that the B-cell responses were suppressed as protective CMI was re-established in the patients during the protracted subclinical infection. According to the data, the diagnosis of subclinical tuberculosis and leprosy may be accomplished using ELISA. The yearly risk of tuberculosis in apparently healthy persons but with significant antibody titers was estimated at 44%; the yearly risk for leprosy has not yet been established. The clinical, epidemiologic, and diagnostic implications of these findings are discussed.