RESUMO
This is a report on eight non-HIV infected leprosy patients presenting unusual co-infection with other, often neglected, tropical diseases, namely: American tegumentary leishmaniasis (ATL), sporotrichosis, and cryptococcosis. To the best of our knowledge, there have been very few ATL-leprosy co-infection reports in the literature to date and only one previous description of the coexistence of leprosy-cryptococcosis and leprosy-sporotricosis.
Assuntos
Criptococose/complicações , Doenças Endêmicas , Leishmaniose Cutânea/complicações , Hanseníase/complicações , Esporotricose/complicações , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Coinfecção , Criptococose/diagnóstico , Feminino , Humanos , Leishmaniose Cutânea/diagnóstico , Hanseníase/diagnóstico , Masculino , Pessoa de Meia-Idade , Doenças Negligenciadas , Estudos Retrospectivos , Esporotricose/diagnóstico , Medicina TropicalRESUMO
The human immunodeficiency virus (HIV) pandemic has disproportionately affected tropical regions of the world, where dermatoses, such as leprosy and leishmaniasis, rarely encountered in temperate climates, are endemic. Although the introduction of highly active antiretroviral therapy (HAART) has been lifesaving, a few patients undergoing HAART experience clinical deterioration caused by immune reconstitution inflammatory syndrome (IRIS). This article explores the range of tropical dermatoses that are reported to date with associated IRIS events.
Assuntos
Terapia Antirretroviral de Alta Atividade/efeitos adversos , Infecções por HIV/complicações , Síndrome Inflamatória da Reconstituição Imune/complicações , Dermatopatias/complicações , Dermatopatias/imunologia , Humanos , Leishmaniose/complicações , Leishmaniose/imunologia , Hanseníase/complicações , Hanseníase/imunologia , Micoses/microbiologia , Penicillium , Esporotricose/complicações , Esporotricose/imunologia , Estrongiloidíase/complicações , Clima TropicalRESUMO
Two adult patients of leprosy, one woman and one man, presented with a clinical picture simulating sporotrichosis. The skin and regional nerve trunk was affected in one, and in the other the disease was confined to the nerve. Both had features of an upgrading reaction following anti-leprosy therapy; this was seen as erosion and scarring of the plaque, and acute onset of abscesses along the easily palpable and thickened nerve that ruptured through the skin. The diagnosis was supported by histopathology. In the light of other infections that give rise to a sporotrichoid pattern of infection it is concluded that leprosy should also be included in this category so that early diagnosis and use of corticosteroids can be implemented quickly to prevent nerve destruction.