Assuntos
Procedimentos Cirúrgicos Dermatológicos/métodos , Emolientes/administração & dosagem , Envelhecimento da Pele/efeitos dos fármacos , Protetores Solares/administração & dosagem , Envelhecimento/efeitos dos fármacos , Envelhecimento/fisiologia , Técnicas Cosméticas , Humanos , Rejuvenescimento/fisiologia , Pele/efeitos dos fármacos , Envelhecimento da Pele/fisiologia , Higiene da Pele/métodos , Fenômenos Fisiológicos da Pele/efeitos dos fármacosRESUMO
Terra firma-forme dermatosis is characterized by 'dirty' brown-grey cutaneous patches and plaques that can simply be eradicated by forceful swabbing with alcohol pads. The pathogenesis has been attributed to abnormal and delayed keratinization. Although affected patients present with typical lesions, the disorder is not well-known by dermatologists. In this report, we describe two patients with terra firma-forme dermatosis in the setting of xerosis cutis and atopic dermatitis. From a clinical point of view, we lay emphasis on its unique expression and diagnosis/treatment. From a histological perspective, we highlight its resemblance to dermatosis neglecta and speculate on the role of 'neglect' in a patient with seemingly adequate hygiene. The role of urea containing emollients in the development of this disorder remains to be determined.
Assuntos
Dermatite Atópica/patologia , Hiperpigmentação/patologia , Ceratose/patologia , Higiene da Pele/métodos , Adulto , Biópsia , Dermatite Atópica/terapia , Feminino , Humanos , Hiperpigmentação/terapia , Ceratose/terapia , Masculino , Pele/patologia , Adulto JovemAssuntos
Dermatite/diagnóstico , Higiene da Pele/métodos , Dermatite/etiologia , Dermatoses Faciais/diagnóstico , Dermatoses Faciais/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Negligenciadas/diagnóstico , Doenças Negligenciadas/etiologia , Medição da Dor , Remissão Espontânea , Medição de Risco , Índice de Gravidade de Doença , Higiene da Pele/efeitos adversos , Neuralgia do TrigêmeoRESUMO
BACKGROUND: Topical corticosteroids (CSs) are the mainstay of therapy in various steroid responsive dermatoses. Newer CSs are more efficacious and safer than the older ones. There is no published data on the efficacy and safety of a new steroid hydrocortisone aceponate in the Indian population. AIM: To evaluate the efficacy and safety of hydrocortisone aceponate (0.127%) lipophilic cream in the treatment of steroid responsive dermatoses in Indian patients. METHODS: Four hundred and fifteen patients with clinically diagnosed steroid responsive dermatoses enrolled in this study. They were advised to apply hydrocortisone aceponate (0.127%) lipophilic cream as a thin film to all the affected areas twice daily. Cleansing was done prior to the application with either soap-free cleanser or soap (that would not affect the study result). Use of oral antihistamines and/or antibiotics was permissible. However, other oral/topical steroid use was not permitted during the study. Patients were evaluated at day 0 and at day 21. Data were recorded regarding clinical improvement and side-effects, if any. They were then analyzed to determine the efficacy and safety of the cream. RESULTS: Physician's global evaluation of therapy showed that lesions were cleared in 82 (22.10%), excellent result in 200 (53.91%), good result in 72 (19.41%), fair response in 15 (4.04%) and no change in 2 (0.54%) patients. There was no history of exacerbation in any patient. CONCLUSION: The study showed that hydrocortisone aceponate (0.127%) lipophilic cream is an effective therapeutic agent with a very good safety profile in various steroid responsive dermatoses in the Indian patient population.