Assuntos
Fármacos Dermatológicos/uso terapêutico , Hiperceratose Epidermolítica/tratamento farmacológico , Ácidos Nicotínicos/uso terapêutico , Administração Tópica , Adolescente , Fármacos Dermatológicos/administração & dosagem , Humanos , Masculino , Ácidos Nicotínicos/administração & dosagem , SíndromeRESUMO
Nevoid hyperkeratosis of the nipple and areola is an unusual condition. Two female patients aged 31 and 18 years presented with chronic unilateral warty lesions of the nipple. One patient had difficulty in breastfeeding from the affected side. A skin biopsy showed acanthosis, hyperkeratosis, papillomatosis and lymphocytic infiltrate in the dermis. There was no significant improvement with topical tretinoin cream in both the patients.
Assuntos
Hiperceratose Epidermolítica/patologia , Nevo/patologia , Mamilos/patologia , Adolescente , Adulto , Doença Crônica , Feminino , Humanos , Hiperceratose Epidermolítica/diagnóstico , Hiperceratose Epidermolítica/tratamento farmacológico , Nevo/diagnóstico , Nevo/tratamento farmacológico , Verrugas/diagnóstico , Verrugas/patologiaRESUMO
In 1937, Siemens described a Dutch family with superficial blistering, flexural hyperkeratosis, and characteristic mauserung appearance. Since then, less than 20 kindreds with this condition have been described in the English dermatologic literature. A 14-year-old boy presented with history of recurrent blistering and peeling of skin since the age of 1 month, predominantly seen over limbs and trunk, often associated with secondary infection. His mother also had similar symptoms from childhood. On examination, the child had typical mauserung peeling of the skin and dirty gray hyperkeratosis in a rippled pattern over flexures. Skin biopsy from the boy showed intracorneal blistering with epidermolytic hyperkeratosis in the upper spinous layers. The typical history and clinical features along with characteristic histological findings confirmed our diagnosis of ichthyosis bullosa of Siemens. It must be differentiated from other conditions with epidermolytic hyperkeratosis and skin peeling, such as bullous ichthyosiform erythroderma of Brocq and peeling skin syndrome. Our patient responded well to 0.05% topical tazarotene gel over four weeks.